Results 131 to 140 of about 6,086,830 (296)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Study the scientific outputs in the field of Persian Gulf in Scopus during 1996-2015 [PDF]

open access: yes, 2018
Background and aim: Findings from studies on science assessment and evaluation are the most important tools for planning and policy-making in each country; therefore, the aim of this study was to investigate the scientific output in the field of Persian ...
Damerchiloo, Mansoureh   +1 more
core  

Evaluation of Scientific Outputs with a Focus at Mass Communication – A Case Study from Slovakia [PDF]

open access: yes
The analytical-polemical extended book review loosely follows the earlier polemic initiated in the Czech journal Filosofi cký časopis and complements the descriptive contribution published in the Slovak journal Otázky žurnalistiky.
Školkay, Andrej
core   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Improving the Discoverability of Practice Research Processes, Outputs, and Data

open access: yes
This presentation was delivered at a Cultural Heritage Open Scholarship Network event on the open access policy environment for Galleries-Libraries-Archives-Museums (GLAMs) and diverse research activities & outputs. This presentation provides an overview
Ranger, H.
core   +1 more source

Scientific output

open access: yes
The results of T6.2 will be described in at least 10 scientific papers (top 25% journals)
openaire   +1 more source

The Influence of Scholarly Output on Scientific Dataset Communication

open access: yes, 2012
Research datasets possess enduring value beyond their originally designed purpose, especially as they typically will never be analyzed or utilized to their fullest potential within a given project time frame. The extent of dataset reuse as a mechanism to understand long-term usefulness within and beyond formal channels of scholarly communication, is an
openaire   +3 more sources

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