Results 121 to 130 of about 715,320 (274)
Jornal de Pediatria, 2012 OBJETIVOS: Realizar análise bibliométrica das teses e dissertações sobre prematuridade no Banco de Teses da Capes no período de 1987 a 2009. MÉTODOS: Estudo de natureza descritiva que utilizou a abordagem bibliométrica para a produção de indicadores ...
Luciana Pizzani +3 more
doaj
Saúde em DebateEste estudo buscou analisar a bibliografia relacionada à avaliação no contexto da Estratégia Saúde da Família, no Brasil, em periódicos de saúde coletiva, de 2003 a 2012.
Elzo Pereira Pinto Junior +4 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
A comparison of the scientific performance of the U. S. and the European Union at the turn of the XXI century. [PDF]
In this paper, scientific performance is identified with the impact journal articles achieve through the citations they receive. The empirical exercise refers to 3.6 million articles published in 1998-2002 in 22 scientific fields, and the more than 47 ...
Albarrán, Pedro +3 more
core
Scientific production on oncology published in the Cuban student journals, 2014-2019
Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2020 Background: the increase in the number of publications in scientific journals has raised the need to carry out periodic assessments of their scientific production or that of a specific area of knowledge.Objective: to characterize the articles on oncology,
Adrián Alejandro Vitón-Castillo +4 more
doaj
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source