Results 61 to 70 of about 216,191 (283)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The Southeastern naturalist and antiquary; being the transactions of the Southeastern union of Scientific Societies, including the proceedings at the annual congress.

, 1896
Ceased publication with v. 70, 1965.Vols. for 1897-1954 include the 1st-59th annual report of the Union.Title varies: 1896, Congress of natural history and scientific societies of the South-East of England; 1897, Transactions of the South-Eastern Union ...
Southeastern Union of Scientific Societies. Transactions., Southeastern Union of Scientific Societies. Proceedings at the annual congress., Southeastern Union of Scientific Societies. Annual report., Southeastern Union of Scientific Societies.   +3 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Health checklist for scientific societies aiming for gender equality.

, 2018
Health checklist for scientific societies aiming for gender equality.
Dominique A. Potvin (3319143), Emily Burdfield-Steel (4398874), Jacqueline M. Potvin (5317685), Stephen M. Heap (5317688)   +3 more
core   +1 more source

Petrograd’s Scientific Societies and the Revolution of 1917

, 2020
The article explores activities of Petrograd’s scientific societies and their relations with changing state power in 1917, especially legal and financial aspects of their functioning and everyday life in the context of an acute socio-political and ...
Sinelnikova, E. F.
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

European project on the competence in pediatric atopic dermatitis management in primary care: Pilot study in a Balkan region

Global Pediatrics
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease that frequently begins in early childhood and imposes a substantial clinical and psychosocial burden on affected patients and their families.
Massimo Pettoello-Mantovani, Tena Niseteo, Georgios Konstantinidis, Donjeta Bali, Angel Carrasco-Sanz, Maria Pastore, Mehmet Vural, Francesca Scaltrito, Tudor Lucian Pop, Giuseppe Buonocore   +9 more
doaj   +1 more source

DEVELOPMENT OF REGIONAL ARCHEOLOGY IN THE SECOND HALF OF XIX - THE FIRST QUARTER OF XX CENTURY (ON MATERIALS OF THE NORTH CAUCASUS)

Гуманитарные и юридические исследования, 2021
The article is devoted to scientific work of central academic institutions, provincial scientific societies and institutions of the North Caucasus in the second half of XIX - the first quarter of the XX century.
L. P. Ermolenko
doaj  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source