Results 101 to 110 of about 11,161,585 (334)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
The Influence of Scientific Theories on Musical Form in Contemporary Instrumental and Electroacoustic Works [PDF]
, 2020 Márta Grabócz
openalex +1 more source
Complexity, Consonance, and the Concept of God [PDF]
, 2012 Complexity theory has much explanatory power in the scientific community today. The author finds that its bottom-up methodology and some of its concepts can facilitate new understandings of the Christian doctrine of the ...
Heltzel, Peter
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
MODERN THEORIES OF SOCIAL GOVERNANCE AS A SCIENTIFIC BASIS FOR THE FORMATION OF A DEMOCRATIC SOCIETY
, 2021 Nigar Gahramanova
openalex +2 more sources
Can Kuhn’s Taxonomic Incommensurability Be an Image of Science? [PDF]
, 2018 I criticize Kuhn’s (1962/1970) taxonomic incommensurability thesis as follows. (i) His argument for it is neither deductively sound nor inductively correct. (ii) It clashes with his account of scientific development that employs evolutionary theory. (iii)
Park, Seungbae
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source