Results 121 to 130 of about 11,161,585 (334)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Methodological problems of the scientific theories analyses
Библиосфера, 2013 The methodological problems of scientific theory are considered. The notion of a scientific theory is analyzed. The principles of classification of scientific theories including internalist, externalist and system theories are revealed.
V. P. Kotenko
doaj
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
The Plague and the City as Forms of Absurdity
Проект Байкал, 2019 Plague epidemics turned the city from the place of recovery to the place of death. The plague was neutralized by chemistry and came back immediately in the loss of the scale, growth in urban territories and roads, and emergence of awful city labyrinths.
Alexander Rappaport
doaj +2 more sources
A review of scientific theories used to justify the delivery of school-based mindfulness programmes. A protocol for a scoping review [PDF]
, 2023 Pamela Abbott +3 more
openalex +1 more source
A Social Process in Science and its Content in a Simulation Program [PDF]
We lay open a position concerning the difference between scientific processes and processes in science. Not all processes in science are scientific. This leads into the center of social simulation.
Klaus Manhart, Wolfgang Balzer
core
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Mark Meerovich and SMD Methodology
Проект Байкал, 2019 The article presents Alexander Rappaport's comments on the article “Mark Meerovich’s System-Based Methodological Approach to the History of Architecture and Town-Planning” written by E. Bagina.
Alexander Rappaport
doaj +2 more sources