Results 51 to 60 of about 11,161,585 (334)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Piękno jako przykład pozaempirycznego kryterium wyboru teorii naukowej
Zagadnienia Filozoficzne w Nauce, 2010 It is sometimes argued that beauty and science have nothing in common. This is not necessarily true. When speaking of beauty in science we are touching two branches of knowledge: aesthetics and physics.
Diana Ciszewska, Marek Szydłowski
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A New Age of Theater Architecture
Проект Байкал, 2020 The article considers the reasons of the change in the form-making principles in architecture of entertainment facilities of the late 20th – early 21st centuries: the change in social conditions, development of stage technologies; improvement of ...
Alexander Anisimov
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“Environmental movement” in architecture and related areas
Проект Байкал, 2021 The concept of “environmental approach” in the theory of architecture, urban planning and design is usually used in the singular, but its content is often interpreted in different ways.
Константин Кияненко
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Practice-oriented controversies and borrowed epistemic credibility in current evolutionary biology: phylogeography as a case study [PDF]
, 2013 Although there is increasing recognition that theory and practice in science are intimately intertwined, philosophy of science perspectives on scientific controversies have been historically focused on theory rather than practice.
Arroyo-Santos, Alfonso +2 more
core +3 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Metaphor as a Factor of Evolutionary Variability of Scientific Theories
АнтиномииThe article analyzes philosophical problems related to the study of the verbalization of new knowledge. Special attention is given to identifying the place and role of metaphor in the linguistic expression of this knowledge.
Alexander M. Zharov
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Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source