Results 81 to 90 of about 11,161,585 (334)
On Scientific Theories and Their Impact on Society
, 2021 Rajendra Kumar Bera
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From The Principle Of Least Action To The Conservation Of Quantum Information In Chemistry: Can One Generalize The Periodic Table? [PDF]
, 2019 The success of a few theories in statistical thermodynamics can be correlated with their selectivity to reality. These are the theories of Boltzmann, Gibbs, end Einstein.
Penchev, Vasil
core
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Kuldiga, the City of the Future
Проект Байкал, 2019 The local population composition in small historic towns will change. Even now, people that can work online settle down in such towns. These very people will save, revitalize and bring new blood in such towns as Kuldiga.
Alexander Rappaport
doaj +2 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
INNOVATIVE SCIENTIFIC RESEARCH: THEORY AND PRACTICE
, 2023 Denis Vladlenov, Denis Vladlenov
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Applying multi-criteria optimisation to develop cognitive models [PDF]
, 2005 A scientific theory is developed by modelling empirical data in a range of domains. The goal of developing a theory is to optimise the fit of the theory to as many experimental settings as possible, whilst retaining some qualitative properties such as ...
Gobet, F, Lane, PCR
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Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
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The widespread opinion that demography is lacking in theory is based in part on a particular view of the nature of scientific theory, generally known as logical empiricism [or positivism].
Thomas K. Burch
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Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source