Results 111 to 120 of about 294,517 (318)

Wired to Wander

open access: yes, 2017
College of Natural ...
The Texas Scientist
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

منهج الشموليية العلمي

open access: yesEskiyeni, 2018
The centers of science, administration and governance are the main agents in any country. The centers of science produce scientists, lead-ers and thinkers if their approach is correct and sound, and the centers of government are the ones that guide the ...
Aydın/ Hüseyin Kudat/ Tarık
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A doctor, a scientist, a teacher and a health care manager — Lev Grigoryevich Gorchakov (to the 100-th birth anniversary) [PDF]

open access: yesСаратовский научно-медицинский журнал, 2017
The aim of the article is to present biographical data of Professor L. G. Gorchakov describing his scientific and practical contribution to the development of Russian Medicine, to the public health organization in Saratov and to the training of medical ...
Yerugina M.V.   +3 more
doaj  

Piney Paradise

open access: yes, 2020
College of Natural ...
The Texas Scientist
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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