Results 241 to 250 of about 316,883 (321)

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

British Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert, Chantal Fitterer, Sylvain Hugel, Mila Jesic, Yannick Goumon, Virgine Andry, Severine Schneider, Francois Daubeuf, Abdelfattah Faouzi, Stephane Doridot, Susruta Majumdar, Frederic Bihel, Martine Schmitt, Dominique Massotte   +13 more
wiley   +1 more source

Recent advances in radionuclide medical imaging techniques. [PDF]

Front Med (Lausanne)
Xu S, Liu G, Wei Q, Liu H, Wu J, Liu Y, He ZX.   +6 more
europepmc   +1 more source

Exploring Large-Volume Gagg Scintillators for Use in Mev Gamma-Ray Astrophysics

Daniel Shy, Richard S. Woolf, Bernard F. Phlips, Mary Johnson-Rambert, Emily Kong   +4 more
openalex   +1 more source

Oceanic spectrum of unstable stratification turbulence with outer scale and scintillation index of Gaussian-beam wave

, 2019
Ye Li, Yixin Zhang, Yun Zhu
openalex   +1 more source

Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Subsets of midbrain dopamine (DA) neurons express the vesicular glutamate transporter VGLUT2 and can release the excitatory neurotransmitter glutamate. VGLUT2+ DA neurons of the substantia nigra pars compacta (SNc) were shown to be more resistant to neurodegeneration in animal models of Parkinson's disease (PD ...
Sivakumar Srinivasan, Christian Pifl, Thomas Steinkellner   +2 more
wiley   +1 more source

First-principles investigation of lead-free Rb₃SbX₆ (X = F, Cl, Br, I) mixed-halide double perovskites promising for photovoltaics and scintillation. [PDF]

RSC Adv
Jehangir MA, Khan MY, Noman M, Lee IE, Wali Q, Usman T, Mu Y, Souwaileh AA.   +7 more
europepmc   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

Workflow designs can facilitate sample management for student-research teams doing taxonomic resource development with Trichoptera. [PDF]

Zookeys
Mendez PK.
europepmc   +1 more source

Oesophageal Epithelial Cell‐Intrinsic MHCII Regulates Food Antigen‐Dependent Eosinophilic Esophagitis in an IFNγ‐Dependent Manner

Clinical &Experimental Allergy, EarlyView.
We found that oesophageal epithelial cells upregulate MHCII expression during active EoE in humans and a mouse model. MHCII expression by EECs was governed by IFNγ‐inducible transcriptional elements. EEC‐intrinsic MHCII promoted regulatory T cell accumulation and attenuated eosinophilic oesophageal inflammation.
Eric M. Rodríguez‐López, Rachel L. Clement, Megha Lal, Yusen Zhou, Stephen D. Carro, Charles‐Antoine Assenmacher, Ravi Gautam, Jarad Beers, Amanda B. Muir, Jonathan M. Spergel, Melanie A. Ruffner, Laurence C. Eisenlohr, David A. Hill   +12 more
wiley   +1 more source

Synergistic effects of Al, Ga, and In doping on ZnO nanorod arrays grown via citrate-assisted hydrothermal technique for highly efficient and fast scintillator screens. [PDF]

Discov Nano
Kurudirek M, Kurudirek SV, Erickson A, Hertel N, Lawrie BJ, Tratsiak Y, Klein B, Melcher CL, Summers CJ, Sellin PJ.   +9 more
europepmc   +1 more source