Results 251 to 260 of about 164,436 (341)

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

Characterization of wrapping and coating techniques for light-reflecting materials of LaBr₃(Ce) scintillation detector. [PDF]

Sci Rep
El-Tayebany RA.
europepmc   +1 more source

APPLICATION OF THE SPECTROMETRIC METHOD FOR CALCULATING THE DOSE RATE FOR CREATING CALIBRATION HIGHLY SENSITIVE INSTRUMENTS BASED ON SCINTILLATION DETECTION UNITS

, 2017
R. V. Lukashevich, G. A. Fokov
openalex   +2 more sources

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

British Journal of Pharmacology, EarlyView.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki, Fumiki Oana, Masaki Oota, Yuma Handa, Osamu Kaminuma   +4 more
wiley   +1 more source

Fractionation and Extraction of Cell Wall Proteins From <i>Candida albicans</i>. [PDF]

Bio Protoc
Reyna-Beltrán E, Iranzo M, Mormeneo S, Bazán-Méndez CI, Labra-Barrios ML, Hernandez-Martínez E, Luna-Arias JP.   +6 more
europepmc   +1 more source

Oesophageal Epithelial Cell‐Intrinsic MHCII Regulates Food Antigen‐Dependent Eosinophilic Esophagitis in an IFNγ‐Dependent Manner

Clinical &Experimental Allergy, EarlyView.
We found that oesophageal epithelial cells upregulate MHCII expression during active EoE in humans and a mouse model. MHCII expression by EECs was governed by IFNγ‐inducible transcriptional elements. EEC‐intrinsic MHCII promoted regulatory T cell accumulation and attenuated eosinophilic oesophageal inflammation.
Eric M. Rodríguez‐López, Rachel L. Clement, Megha Lal, Yusen Zhou, Stephen D. Carro, Charles‐Antoine Assenmacher, Ravi Gautam, Jarad Beers, Amanda B. Muir, Jonathan M. Spergel, Melanie A. Ruffner, Laurence C. Eisenlohr, David A. Hill   +12 more
wiley   +1 more source

Point Dosimetry in Patient-specific Quality Assurance of a Robotic Radiosurgery System Using a Scintillation Detector. [PDF]

J Med Phys
Okawa K, Hirota Y.
europepmc   +1 more source

‘I like to dance with the flowers!’: Exploring the possibilities for biodiverse futures in an urban forest school

Children &Society, EarlyView.
Abstract This article explores the ways in which ‘forest school’, an educational approach where children engage in creative and play based activities in a ‘natural’ environment, can contribute towards Sustainable Development Goal 15 (SDG 15) by promoting sustainable use of terrestrial ecosystems and by helping address biodiversity loss. Drawing on data
Hannah Hogarth
wiley   +1 more source

Unlocking radioluminescence in copper cyclic trinuclear complexes. [PDF]

Sci Adv
Chen YX, Li YG, Fan J, Zhuo H, Zhou Z, Tong H, Yang M, Li WG, Wu J, Pang H, Liu W, Wu C, Tian T, Ouyang G.   +13 more
europepmc   +1 more source

Talking Fanart: Small Stories About Drawings and Games

Children &Society, EarlyView.
ABSTRACT The present paper investigates small stories of Minecraft fanart as a part of children's gaming practices. The data consists of interviews with ten Swedish children between 10 and 18 years old about the creation of digital drawings. Taking an ethnomethodological and conversation analytical approach paper directs attention to how Finley talks ...
Pål Aarsand
wiley   +1 more source