Results 121 to 130 of about 679,715 (383)

The time-of-flight system on the Goddard medium energy gamma-ray telescope [PDF]

open access: yes
A scintillation counter time of flight system, incorporated into the Goddard 50 cm by 50 cm spark chamber gamma ray telescope is described. The system, which utilizes constant fractions timing and particle position compensation and digitizes up to 10 ns ...
Chesney, J. R., Ross, R. W.
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang   +7 more
wiley   +1 more source

Glial Versus Neuronal Na+/K+‐ATPase in Activity‐Evoked K+ Clearance and Their Sensitivity to Elevated Extracellular K+

open access: yesGlia, EarlyView.
The glial Na+ pump regulates [K+]o during neuronal activity, and the neuronal version restores [K+]o to baseline. Spreading depression‐related rise of K+ does not cause SD propagation via suppression of Na+/K+‐ATPase or glutamate transport. ABSTRACT Neuronal activity in the central nervous system is associated with a [K+]o transient that is swiftly ...
Brian Skriver Nielsen   +6 more
wiley   +1 more source

In Vitro and Clinical Evaluations of UGT1A1‐, P‐gp‐, OATP1B1‐, and BCRP‐Mediated Drug–Drug Interactions of Belumosudil, a Potent ROCK2 Inhibitor

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Belumosudil is an oral selective rho‐associated coiled‐coil containing protein kinase 2 inhibitor, approved as a treatment for chronic graft‐versus‐host disease. Prior clinical studies demonstrated that coadministration with strong CYP3A4 inducers or proton pump inhibitors requires dose modification of belumosudil.
Olivier Schueller   +4 more
wiley   +1 more source

Groundwater renewal time by environmental tritium isotopes as a tracer for sustainable water resource management

open access: yesDiscover Water
Studying groundwater renewal time is a valuable tool to deepen the comprehension of sustainable groundwater resources specific to arid regions. Tritium is a radioactive isotope of hydrogen often used as an environmental tracer to study groundwater ...
Al Mamun
doaj   +1 more source

Dating the Middle Palaeolithic of Fumane Cave by the combined ESR/U‐series method

open access: yesJournal of Quaternary Science, EarlyView.
ABSTRACT Fumane Cave, located in Northern Italy, is a major prehistoric site for understanding late Neandertal and early modern human behaviours. The cave contains a 12‐m‐thick stratigraphic sequence of Middle and Upper Palaeolithic layers, which have yielded a number of flint artefacts and faunal remains.
Christophe Falguères   +4 more
wiley   +1 more source

Aquatic heatwaves increase surface chlorophyll concentrations in experimental and reference lakes

open access: yesLimnology and Oceanography Letters, EarlyView.
Abstract Aquatic heatwaves are increasing in frequency, intensity, and duration worldwide. While increases in mean water temperatures are linked to enhanced phytoplankton biomass, it is unclear how heatwaves alter phytoplankton dynamics in lakes at an ecosystem scale.
Daniel K. Szydlowski   +3 more
wiley   +1 more source

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