Results 151 to 160 of about 118,484 (324)

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

Studies of Quenching on Liquid Scintillation Counter

, 1977
J. Saito, Ko Taki
openalex   +2 more sources

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

British Journal of Pharmacology, EarlyView.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki, Fumiki Oana, Masaki Oota, Yuma Handa, Osamu Kaminuma   +4 more
wiley   +1 more source

Oesophageal Epithelial Cell‐Intrinsic MHCII Regulates Food Antigen‐Dependent Eosinophilic Esophagitis in an IFNγ‐Dependent Manner

Clinical &Experimental Allergy, EarlyView.
We found that oesophageal epithelial cells upregulate MHCII expression during active EoE in humans and a mouse model. MHCII expression by EECs was governed by IFNγ‐inducible transcriptional elements. EEC‐intrinsic MHCII promoted regulatory T cell accumulation and attenuated eosinophilic oesophageal inflammation.
Eric M. Rodríguez‐López, Rachel L. Clement, Megha Lal, Yusen Zhou, Stephen D. Carro, Charles‐Antoine Assenmacher, Ravi Gautam, Jarad Beers, Amanda B. Muir, Jonathan M. Spergel, Melanie A. Ruffner, Laurence C. Eisenlohr, David A. Hill   +12 more
wiley   +1 more source

‘I like to dance with the flowers!’: Exploring the possibilities for biodiverse futures in an urban forest school

Children &Society, EarlyView.
Abstract This article explores the ways in which ‘forest school’, an educational approach where children engage in creative and play based activities in a ‘natural’ environment, can contribute towards Sustainable Development Goal 15 (SDG 15) by promoting sustainable use of terrestrial ecosystems and by helping address biodiversity loss. Drawing on data
Hannah Hogarth
wiley   +1 more source

Solid scintillator "Ready Cap" for measurement with a liquid scintillation counter. Spectra and counting efficiencies for 15 different radionuclides.

, 1990
Kenichi Ijiri, Masashi Endo, Susumu Osaki, Norio Nogawa, Shoko TSUDA, Aiko NAKAMURA, Naotake MORIKAWA   +6 more
openalex   +2 more sources

Facilitated Transport of Organic Contaminants in a High Concentration, Multicomponent Plume

Groundwater Monitoring &Remediation, EarlyView.
Abstract A field experiment evaluated the transport of organic contaminants in a plume from hazardous waste disposal areas at the Rocky Mountain Arsenal. The plume contained many xenobiotic contaminants, with widely varying expected mobilities.
D. M. Mackay, B. Myller, G. C. Bianchi‐Mosquera, B. D. Honeyman, M. Schirmer, R. M. Allen‐King, W. P. Ball, R. L. Stollar   +7 more
wiley   +1 more source

Calculation the mass attenuation coefficient of beta-particles through Polyvinyl chloride

Iraqi Journal of Physics, 2010
The mass attenuation coefficient for beta particles through pure Polyvinyl chloride (PVC) and flax fibers- reinforced PVC composite were investigated as a function of the absorber thickness and the absorber to source distance.
Ban M. Alshabander
doaj  

TRITIUM ANALYSIS IN URINE BY THE TRIPLE-TO-DOUBLE COINCIDENCE RATIO METHOD WITH THE HIDEX 300 SL LIQUID SCINTILLATION COUNTER

, 2019
Yannick Lecompte, Martine Rosset, Jérôme Loess, Nadine Chianea, Flora Jourquin, A. Cazoulat, P. Cassette   +6 more
openalex   +2 more sources

Quality control for measurements of tritium in water samples by liquid scintillation counter

, 2022
Marija Lekić, Nevena Zdjelarević, Jelena Đorđević, Nataša Lazarević, Dalibor Arbutina   +4 more
openalex   +1 more source