Results 111 to 120 of about 47,910 (271)

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, EarlyView.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

Co‐Firing Slow Solidification Process for Growing Indium‐Doped Cs3Cu2I5 Single Crystals With Record‐Breaking X‐Ray Detection Performance

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A novel brand‐new co‐firing slow solidification process has been used to prepare Cs3Cu2I5: In single crystals (SCs), which demonstrate record‐breaking X‐ray detection performance. The regular‐shaped Cs3Cu2I5: In wafer obtains a high light yield (74 368 Ph MeV−1), which is the highest related to indium‐doped Cu‐based perovskites.
Rui Liu, Zhiyong Liu, Chengxu Lin, Chenyu Li, Tielin Shi, Xingyue Liu, Guanglan Liao   +6 more
wiley   +1 more source

Nanofiber PVA‐Based Membranes Incorporating Functionalized Spanish Broom Derivatives for Sustainable Water Purification

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This study investigates Spanish broom (Spartium junceum) as a renewable source for electrospun composite membranes in sustainable water purification. MCC and biochar were functionalized with eco‐friendly precursors and nanomaterials (i.e., HNT, β‐CDs) to develop hybrid PVA nanofiber composites.
Giulia Rando, Silvia Sfameni, Jozefien Geltmeyer, Alessandra Palella, Lorenzo Spadaro, Alberto Riminucci, Karen De Clerck, Maria Rosaria Plutino   +7 more
wiley   +1 more source

A European X-ray astrophysics mission [PDF]

Five instruments (Bragg Spectrometer, Large Area Proportional and Scintillation Counter Detectors, Wide Field X-ray Cameras and a Gamma-Ray Burst Monitor) are discussed and estimates of their performance are given.
Culhane, J. L.
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Effect of Ammonium Polyphosphate/Silicate Content on the Postfire Mechanics of Epoxy Glass‐Fiber Composites Using Facile Chocolate Bar‐Inspired Structures

Fire and Materials, Volume 49, Issue 3, Page 329-346, April 2025.
ABSTRACT This study investigates the postfire mechanical properties of epoxy glass‐fiber reinforced composites (EP GFRCs) using increasing concentrations of ammonium polyphosphate (APP) and inorganic silicate (InSi) to modify the char and fire residue.
Sruthi Sunder, Maria Jauregui Rozo, Sneha Inasu, Dietmar Meinel, Bernhard Schartel, Holger Ruckdäschel   +5 more
wiley   +1 more source

Modeling Photo-multiplier Gain and Regenerating Pulse Height Data for Application Development

EPJ Web of Conferences, 2018
Systems that adopt organic scintillation detector arrays often require a calibration process prior to the intended measurement campaign to correct for significant performance variances between detectors within the array.
Aspinall Michael D., Jones Ashley R.
doaj   +1 more source

Wonder as a Gateway to Science Meaning‐Making: Primary Pupils’ Narrative Journeys

Future in Educational Research, EarlyView.
ABSTRACT This study explores how wonder fosters transformative learning in science education for pupils (11–12 years old), creating meaning about cycles in nature. As an emotional and epistemic trigger, wonder may bridge everyday experiences with abstract scientific concepts by stimulating curiosity and creativity. Through a narrative writing task, the
Pauline Book, Siri‐Christine Seehuus
wiley   +1 more source

Hypervision Proton Surgery: The Future Direction of Proton Therapy

iNew Medicine, EarlyView.
ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley   +1 more source

The Non‐Professional Virtues of the Hospice Volunteer

Journal of Applied Philosophy, EarlyView.
ABSTRACT Volunteers have long played a significant role in hospice care. Much of the care volunteers provide consists of weekly hour‐long in‐home visits. Home‐visiting hospice volunteers are not professionals, nor are they strangers or intimates. Hospice volunteers will not typically face moral dilemmas, nor be called upon to make dramatic decisions ...
Michael B. Gill
wiley   +1 more source