Results 51 to 60 of about 15,963 (349)

Predicting transport effects of scintillation light signals in large-scale liquid argon detectors

European Physical Journal C: Particles and Fields, 2021
Liquid argon is being employed as a detector medium in neutrino physics and Dark Matter searches. A recent push to expand the applications of scintillation light in Liquid Argon Time Projection Chamber neutrino detectors has necessitated the development ...
Diego Garcia-Gamez, Patrick Green, Andrzej M. Szelc   +2 more
doaj   +1 more source

Requirements of Scintillation Crystals with the Development of PET Scanners

Crystals, 2022
Positron emission tomography (PET) is widely used in the diagnosis of tumors, cardiovascular system diseases, and neurological diseases. Scintillation crystals are an important part of PET scanners; they can convert γ photons into fluorescent photons to ...
Xin Yu, Xi Zhang, Heng Zhang, Hao Peng, Qiushi Ren, Jianfeng Xu, Qiyu Peng, Siwei Xie   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Large-scale liquid scintillation detectors for solar neutrinos

, 2016
Large-scale liquid scintillation detectors are capable of providing spectral yields of the low energy solar neutrinos. These detectors require > 100 tons of liquid scintillator with high optical and radiopurity.
Frank P. Calaprice, Jay B. Benziger
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

The Complex of Experimental Facilities for the Cosmic Ray Investigation at the Tien Shan Mountain Station

Applied Sciences, 2022
The study describes the experimental complex of the station located in the Tien Shan mountains at an elevation of 3340 m above sea level. The complex consists of detectors of different types scattered across the station area, such as scintillation ...
Kanat Mukashev, Alia Argynova, Valery Zhukov, Tunyk Idrissova, Bakhtiyar Iskakov, Vecheslav Piskal, Turlan Sadykov, Zhakypbek Sadykov, Alexey Stepanov, Abai Serikkanov   +9 more
doaj   +1 more source

Characterization of wrapping and coating techniques for light-reflecting materials of LaBr₃(Ce) scintillation detector. [PDF]

Sci Rep
El-Tayebany RA.
europepmc   +3 more sources

The UA2 scintillating fibre detector

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1988
Abstract The UA2 experiment at CERN is currently upgrading its apparatus to take advantage of the higher accelerator luminosity to be provided from November 1987. The first large particle tracking detector using scintillating optical fibres will form a major part of this upgrade. The detector is built by the Cambridge, CERN and Saclay groups.
R.E. Ansorge, C. Anrouet, P. Bareyre, P. Bonamy, C.N. Booth, M. Bouchard, M. Bourdinaud, M. Cordier, J. Crittenden, R.S. Dewolf, J. Dupont, J. Dupraz, K. Einsweiler, C. Engster, J-P. Fabre, J-M. Gaillard, J-L. Garavel, K. Hultqvist, C. Jeanney, S.G. Katvars, M. Lefebvre, L. Linssen, B. McCluskey, B. Merkel, J-P. Meyer, D.J. Munday, P. Nappey, J.M. Pentney, S. Reynaud, J.G. Rushbrooke, J-C. Thevenin, W.Y. Tsang, A.R. Weidberg, P.S. Wells, S.A. Wotton, T.O. White, H. Zaccone   +36 more
openaire   +2 more sources

Microstructural Evolution and Vacancy Defect Formation in Mn–Mo–Ni RPV Steel Under Low Cycle Fatigue: Insights From EBSD and PALS

Advanced Engineering Materials, EarlyView.
Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar, Dhanadeep Dutta, G. Bharat Reddy   +2 more
wiley   +1 more source