Results 41 to 50 of about 3,241 (305)

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

GNSS-R Altimetry Performance Analysis for the GEROS Experiment on Board the International Space Station

Sensors, 2017
The GEROS-ISS (GNSS rEflectometry, Radio Occultation and Scatterometry onboard International Space Station) is an innovative experiment for climate research, proposed in 2011 within a call of the European Space Agency (ESA).
Adriano Camps, Hyuk Park, Ivan Sekulic, Juan Manuel Rius   +3 more
doaj   +1 more source

Microstructural Evolution and Vacancy Defect Formation in Mn–Mo–Ni RPV Steel Under Low Cycle Fatigue: Insights From EBSD and PALS

Advanced Engineering Materials, EarlyView.
Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar, Dhanadeep Dutta, G. Bharat Reddy   +2 more
wiley   +1 more source

On the Properties of and Ionospheric Conditions Associated With a Mid‐Latitude Scintillation Event Observed Over Southern United States

Space Weather, 2021
While low and high‐latitude ionospheric scintillation have been extensively reported, significantly less information is available about the properties of and conditions leading to mid‐latitude scintillations.
F. S. Rodrigues, J. G. Socola, A. O. Moraes, C. Martinis, D. A. Hickey   +4 more
doaj   +1 more source

Strong Coupling in Bulk Nanoplasmonic Nanoplatelet Perovskite Scintillators

Advanced Materials, EarlyView.
A bulk scintillating nanocomposite is engineered from CsPbBr3 nanoplatelets and Ag nanocubes to support exciton–plasmon strong coupling under X‐ray excitation. The resulting hybrid polaritonic states appear directly in radioluminescence, opening a route toward polariton‐enabled scintillator design beyond conventional Purcell enhancement.
Michal Makowski, Dominik Kowal, Anna Pniakowska, Kamil Misztal, Mohanad Saadeldin Eid, Joanna Cybinska, Winicjusz Drozdowski, Benoit Mahler, Christophe Dujardin, Detlef Hommel, Liang Jie Wong, Dennis Schaart, Sergio Brovelli, Muhammad Danang Birowosuto   +13 more
wiley   +1 more source

Multi-instrument observations of ionospheric super plasma bubbles in the European longitude sector during the 23–24 April 2023 severe geomagnetic storm

Journal of Space Weather and Space Climate
This study’s objective is to better specify the rare occurrence of super equatorial plasma bubbles in particular to the European longitude sector, detailing their spatio-temporal evolution, and better understanding pre-conditions for their development ...
Zakharenkova Irina, Cherniak Iurii, Braun John J., Wu Qian, Sokolovskiy Sergey, Hunt Douglas, Weiss Jan-Peter   +6 more
doaj   +1 more source

GNSS Ionosphere Sounding of Equatorial Plasma Bubbles

Atmosphere, 2019
Ground- and space-based Global Navigation Satellite System (GNSS) receivers can provide three-dimensional (3D) information about the occurrence of equatorial plasma bubbles (EPBs).
Guanyi Ma, Klemens Hocke, Jinghua Li, Qingtao Wan, Weijun Lu, Weizheng Fu   +5 more
doaj   +1 more source

Advances in Halide Perovskites for Photon Radiation Detectors

Advanced Materials Technologies, EarlyView.
This work highlights recent progress in perovskite‐based photon radiation detectors, covering organic–inorganic hybrid, inorganic, lead‐free double, and vacancy‐ordered halide perovskites. Their detection performance is compared, material‐specific advantages and challenges are examined, and provides insight into current limitations and future ...
Liangling Wang, Jieqi Wang, Xiaojun Cui, Carsten Ronning   +3 more
wiley   +1 more source

Characteristics of VHF scintillations in the equatorial anomaly crest region in India [PDF]

Annales Geophysicae, 1995
The characteristics of ionospheric scintillations at Rajkot in the equatorial anomaly crest region in India are described for the years 1987–1991 by monitoring the 244-MHz transmission from the satellite FLEETSAT.
K. N. Pathak, R. D. Jivrajani, H. P. Joshi, K. N. Iyer   +3 more
doaj   +1 more source