Results 271 to 280 of about 120,503 (315)

A somatic multiple myeloma mutation unravels a mechanism of oligomerization‐mediated product inhibition in GGPPS

The FEBS Journal, EarlyView.
Geranylgeranyl diphosphate synthase (GGPPS) plays a key role in multiple myeloma biology. Using crystallography, mass spectrometry, and fluorescence spectroscopy, this study shows that a somatic multiple myeloma cell line mutation destabilizes inter‐dimer interactions, resulting in increased GGPPS activity by facilitating product releas.
Ruba Yehia, Jasmína Mária Portašiková, Rut Mor Yosef, Benny Da'adoosh, Alan Kádek, Petr Man, Moshe Giladi, Yoni Haitin   +7 more
wiley   +1 more source

Image quality evaluation of imaging skins, a novel stretchable X-ray detector for intraoperative tumour imaging. [PDF]

Sci Rep
Dietsch S, Allan H, Lindenroth L, Moss R, Stilli A, Stoyanov D.   +5 more
europepmc   +1 more source

Characterisation of Geological Samples with Dual‐Energy XCT: A Comparison of Three Different Scanners

Geostandards and Geoanalytical Research, EarlyView.
Key Points A stoichiometric calibration method for dual‐energy computed tomography allows non‐destructive characterisation of materials. Different acquisition settings and three different scanners were tested, characterising three rocks of known composition. Comparison of measurement results reveals the key parameters to be considered to perform useful
Margherita Martini, Pierre Francus, Laurenz Schröer, Florian Buyse, Pierre Kibleur, Veerle Cnudde, Leonardo Di Schiavi Trotta, Philippe Després   +7 more
wiley   +1 more source

LumaCam: a novel class of position-sensitive event mode particle detectors using scintillator screens. [PDF]

Sci Rep
Wolfertz A, Gustschin A, Schulz M, Long AM, Khaplanov A, Hirsh TY, Nomerotski A, Morgano M, Tremsin A, Mauri G, Sykora GJ, Losko A.   +11 more
europepmc   +1 more source

A novel approach to target skin photodamage: Topical application of salt inducible kinase inhibitors

International Journal of Cosmetic Science, EarlyView.
UV‐induced photodamage leads to increased DNA damage and elevated MMP levels, which degrade collagen and contribute to wrinkle formation. SLT‐001 and SLT‐008, novel cosmetic ingredients that target salt‐inducible kinase, help reverse this effect by enhancing DNA repair, reducing MMP expression and decreasing erythema, thereby mitigating photodamage ...
Inbal Rachmin, Béatrice Le Varlet, Claire Regazzetti, Thierry Passeron, Jinhua Wang, David E. Fisher, Philippe Schaison, Braham Shroot   +7 more
wiley   +1 more source

Development of an omnidirectional rotating Compton camera for imaging 177Lu radioactive contamination. [PDF]

PLoS One
Tsukamoto H, Muraishi H, Enomoto R, Katagiri H, Kagaya M, Watanabe T, Mizoguchi T, Fukumoto M, Kano D, Watanabe Y, Sakaguchi K, Ishiyama H.   +11 more
europepmc   +1 more source

Slip casting porous silicon nitride for high‐temperature radar frequency radomes

International Journal of Applied Ceramic Technology, EarlyView.
Abstract Silicon nitride (Si3N4) is a promising candidate for ceramic radar frequency (RF) radomes. In this study, suspensions have been developed to slip cast Si3N4 for RF windows utilizing 6 wt.% yttrium oxide (Y2O3)‐2 wt.% aluminum oxide (Al2O3) and 5–15 wt.% ytterbium oxide sintering aids.
Averyonna R Kimery, Matthew A Thompson, Carlos J Martinez, Rodney W Trice   +3 more
wiley   +1 more source

Charge-separated state trap: a new strategy for constructing high-performance organic scintillators. [PDF]

Natl Sci Rev
Tang Z.
europepmc   +1 more source

MHC I of the Great Reed Warbler Promotes a Flat Peptide Binding Mode

Immunology, EarlyView.
In this article we present the X‐ray structure of MHC I from the great reed warbler Acrocephalus arundinaceus (Acar3) a long‐distance migratory songbird. Structural analysis in combination with genetic analyses shows that MHC I binds the peptide antigen in a flat conformation due to a sequentially well‐conserved restriction point, acting like a pair of
Raminta Venskutonytė, Sven Kjellström, Emily Amelia O'Connor, Helena Westerdahl, Karin Lindkvist‐Petersson   +4 more
wiley   +1 more source