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[Localized scleroderma].

Dermatologie (Heidelberg, Germany)
Localized scleroderma (LS), also called circumscribed scleroderma or morphea, comprises a heterogeneous group of diseases that can be classified into four subtypes: limited, linear, generalized, and mixed LS. All manifestations are primarily due to chronic progressive fibrosis of the skin or structures close to the skin.
Suzan, Al-Gburi   +2 more
openaire   +3 more sources

Juvenile Localized Scleroderma

Rheumatic Disease Clinics of North America, 2021
Natalia Vasquez-Canizares, Suzanne C. Li
openaire   +2 more sources

Cross‐sectional quantitative validation of the paediatric Localized Scleroderma Quality of Life Instrument (LoSQI): A disease‐specific patient‐reported outcome measure

Journal of the European Academy of Dermatology and Venereology, 2023
The Localized Scleroderma Quality of Life Instrument (LoSQI) is a disease‐specific patient‐reported outcome (PRO) measure designed for children and adolescents with localized scleroderma (LS; morphea).
C. Zigler   +10 more
semanticscholar   +1 more source

Capturing the Range of Disease Involvement in Localized Scleroderma: The Localized Scleroderma Total Severity Scale

Arthritis care & research, 2023
Juvenile localized scleroderma (jLS) is a chronic autoimmune disease commonly associated with poor outcomes, including contractures, hemiatrophy, uveitis, and seizures.
Suzanne C. Li   +16 more
semanticscholar   +1 more source

Adipose-Derived Stem Cells Attenuate Skin Fibrosis and Improve Fat Retention of a Localized Scleroderma Mouse Model

Plastic and Reconstructive Surgery, 2022
Background: Although autologous fat grafting is a feasible surgical technique to improve facial deformity in patients with localized scleroderma, its success is limited by the low graft retention induced by the local inflammatory environment.
H. C. Wang   +7 more
semanticscholar   +1 more source

Localized scleroderma: actual insights and new biomarkers

International Journal of Dermatology, 2021
Localized scleroderma (LS, morphea, limited scleroderma, focal scleroderma) is a chronic autoimmune disease characterized by a progressive damage to the connective tissue with a predominance of fibrosclerotic disorders in the skin and the subcutaneous ...
E. Snarskaya, K. Vasileva
semanticscholar   +1 more source

Extracutaneous Involvement Is Common and Associated with Prolonged Disease Activity and Greater Impact in Juvenile Localized Scleroderma.

Rheumatology, 2021
OBJECTIVE To evaluate factors associated with extracutaneous involvement (ECI) in juvenile localized scleroderma (jLS). METHODS A prospective, multi-center, 6-month observational study was performed.
Suzanne C. Li   +10 more
semanticscholar   +1 more source

Aesthetic and therapeutic outcome of fat grafting for localized Scleroderma treatment: From basic study to clinical application

Journal of Cosmetic Dermatology, 2021
Localized scleroderma (LoS) is a rare autoimmune disease characterized by skin fibrosis and subcutaneous tissue atrophy, resulting in aesthetic impairment on patients.
H. C. Wang   +3 more
semanticscholar   +1 more source

Transcriptomic Evaluation of Juvenile Localized Scleroderma Skin With Histologic and Clinical Correlation

Arthritis & Rheumatology, 2021
Juvenile localized scleroderma (LS) is an autoimmune disease of the skin whose pathogenesis is not well understood due to the rarity of the disease. This study was undertaken to determine the skin transcriptome in skin biopsy tissue from children with ...
Christina Schutt   +8 more
semanticscholar   +1 more source

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