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Current Opinion in Rheumatology, 2006
Localized scleroderma, also known as morphoea, has a variety of clinical manifestations that can include systemic involvement. Early recognition, diagnosis and treatment may improve the long-term outcome.A large multicentre study coordinated by the Pediatric Rheumatology European Society has yielded important information on the epidemiology and ...
Francesco Zulian, Ronald M. Laxer
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Localized scleroderma, also known as morphoea, has a variety of clinical manifestations that can include systemic involvement. Early recognition, diagnosis and treatment may improve the long-term outcome.A large multicentre study coordinated by the Pediatric Rheumatology European Society has yielded important information on the epidemiology and ...
Francesco Zulian, Ronald M. Laxer
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Current Opinion in Rheumatology, 1989
Localized scleroderma has no recognized internal organ involvement. It may rarely coexist with a systemic connective tissue disease, but is not thought to progress to systemic sclerosis. Although never fatal, localized scleroderma may cause considerable disability from joint contractures and subcutaneous atrophy.
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Localized scleroderma has no recognized internal organ involvement. It may rarely coexist with a systemic connective tissue disease, but is not thought to progress to systemic sclerosis. Although never fatal, localized scleroderma may cause considerable disability from joint contractures and subcutaneous atrophy.
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Congenital localized scleroderma
The Journal of Pediatrics, 2006Juvenile localized scleroderma (JLS) usually has its onset during later childhood. This report describes the clinical and serologic features of six children with congenital localized scleroderma (CLS).A large, multinational study was conducted among pediatric rheumatology and dermatology centers by collecting information on demographics, family history,
Zulian F +8 more
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The Prognosis of Localized Scleroderma
Archives of Dermatology, 1958While much interest has been given to the generalized systemic forms of scleroderma, relatively little information has appeared about localized scleroderma. Reports concerning the use of various therapeutic agents in localized scleroderma continue to appear, but with a limited knowledge of the natural course of the untreated disease and often a lack of
Thomas G. Jansen, Arthur C. Curtis
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Systemic and localized scleroderma
Clinics in Dermatology, 2006Sclerosing conditions of the skin are manifested by a full spectrum of presentations that includes skin-limited forms as well as those which can involve internal organs and result in death. At this point, we are just beginning to understand the mechanisms of tissue fibrosis, and it is likely that the fibrotic processes are a heterogeneous group of ...
Lorinda Chung +3 more
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Localized and systemic scleroderma
Seminars in Cutaneous Medicine and Surgery, 2001Scleroderma is a broad term encompassing both localized and systemic sclerosis. Localized scleroderma is a cutaneous limited fibrosis that manifests as plaque morphea, generalized morphea, linear scleroderma, and deep morphea. Systemic scleroderma (sclerosis) can manifest as either limited or diffuse disease.
J C English rd, A Hawk
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Management of localized scleroderma
Seminars in Cutaneous Medicine and Surgery, 1998Localized scleroderma denotes a spectrum of conditions characterized by circumscribed fibrotic areas involving different levels of the dermis, subcutis, and sometimes underlying soft tissue and bone. Although the clinical course of the disease is often benign, widespread lesions and disabling joint contractures may lead to significant complications ...
Krieg T +3 more
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Preliminary Evidence on Abatacept Safety and Efficacy in Refractory Juvenile Localized Scleroderma.
Rheumatology, 2020OBJECTIVES To evaluate the safety and efficacy of abatacept treatment for refractory juvenile localized scleroderma (jLS) in a retrospective study. METHODS A multicentre cohort study was performed to evaluate jLS subjects treated with abatacept with ...
Suzanne C. Li +7 more
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Borrelia burgdorferi and localized scleroderma
Clinics in Dermatology, 1994L yme borreliosis is a multisystemic disorder caused by the spirochete Borrelia burgdorferi and transmitted by the Ixodes tick. The initial manifestations of the disease are the characteristic skin lesion, erythema migrans, and symptoms of general malaise (stage I).
TREVISAN, GIUSTO +2 more
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British Journal of Dermatology, 2020
Paediatric localized scleroderma (LS) can negatively impact health‐related quality of life (HRQoL) by causing skin fibrosis, abnormal limb development, disfigurement, and side‐effects from immunosuppressive treatment. Studies to date have rarely included
C. Zigler +7 more
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Paediatric localized scleroderma (LS) can negatively impact health‐related quality of life (HRQoL) by causing skin fibrosis, abnormal limb development, disfigurement, and side‐effects from immunosuppressive treatment. Studies to date have rarely included
C. Zigler +7 more
semanticscholar +1 more source