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Preliminary Evidence on Abatacept Safety and Efficacy in Refractory Juvenile Localized Scleroderma.
Rheumatology, 2020OBJECTIVES To evaluate the safety and efficacy of abatacept treatment for refractory juvenile localized scleroderma (jLS) in a retrospective study. METHODS A multicentre cohort study was performed to evaluate jLS subjects treated with abatacept with ...
Suzanne C. Li +7 more
semanticscholar +1 more source
British Journal of Dermatology, 2020
Paediatric localized scleroderma (LS) can negatively impact health‐related quality of life (HRQoL) by causing skin fibrosis, abnormal limb development, disfigurement, and side‐effects from immunosuppressive treatment. Studies to date have rarely included
C. Zigler +7 more
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Paediatric localized scleroderma (LS) can negatively impact health‐related quality of life (HRQoL) by causing skin fibrosis, abnormal limb development, disfigurement, and side‐effects from immunosuppressive treatment. Studies to date have rarely included
C. Zigler +7 more
semanticscholar +1 more source
Dermatologic therapy, 2012
Localized scleroderma (also called morphea) is a term encompassing a spectrum of sclerotic autoimmune diseases that primarily affect the skin, but also might involve underlying structures such as the fat, fascia, muscle, and bones. Its exact pathogenesis is still unknown, but several trigger factors in genetically predisposed individuals might ...
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Localized scleroderma (also called morphea) is a term encompassing a spectrum of sclerotic autoimmune diseases that primarily affect the skin, but also might involve underlying structures such as the fat, fascia, muscle, and bones. Its exact pathogenesis is still unknown, but several trigger factors in genetically predisposed individuals might ...
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Systemic and localized scleroderma
Clinics in Dermatology, 2006Sclerosing conditions of the skin are manifested by a full spectrum of presentations that includes skin-limited forms as well as those which can involve internal organs and result in death. At this point, we are just beginning to understand the mechanisms of tissue fibrosis, and it is likely that the fibrotic processes are a heterogeneous group of ...
Lorinda, Chung +3 more
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Localized and systemic scleroderma
Seminars in Cutaneous Medicine and Surgery, 2001Scleroderma is a broad term encompassing both localized and systemic sclerosis. Localized scleroderma is a cutaneous limited fibrosis that manifests as plaque morphea, generalized morphea, linear scleroderma, and deep morphea. Systemic scleroderma (sclerosis) can manifest as either limited or diffuse disease.
A, Hawk, J C, English
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Management of localized scleroderma
Seminars in Cutaneous Medicine and Surgery, 1998Localized scleroderma denotes a spectrum of conditions characterized by circumscribed fibrotic areas involving different levels of the dermis, subcutis, and sometimes underlying soft tissue and bone. Although the clinical course of the disease is often benign, widespread lesions and disabling joint contractures may lead to significant complications ...
N, Hunzelmann +3 more
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Archives of Dermatology, 1966
A case of linear and morphea scleroderma is reported. Histochemical studies revealed an increase of positive PAS material, diastase resistant, in the areas of homogenized collagen. Chemical analysis suggests an increase in hexoses and hexosamines, probably bound to the collagen fibers.
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A case of linear and morphea scleroderma is reported. Histochemical studies revealed an increase of positive PAS material, diastase resistant, in the areas of homogenized collagen. Chemical analysis suggests an increase in hexoses and hexosamines, probably bound to the collagen fibers.
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Localized scleroderma: Imaging features
Pediatric Radiology, 1994Localized scleroderma is distinct from the diffuse form of scleroderma and does not show Raynaud's phenomenon and visceral involvement. The imaging features in 23 patients ranging from 2 to 17 years of age (mean 11.1 years) were reviewed. Leg length discrepancy and muscle atrophy were the most common findings (five patients), with two patients also ...
P, Liu +5 more
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Borrelia burgdorferi and localized scleroderma
Clinics in Dermatology, 1994L yme borreliosis is a multisystemic disorder caused by the spirochete Borrelia burgdorferi and transmitted by the Ixodes tick. The initial manifestations of the disease are the characteristic skin lesion, erythema migrans, and symptoms of general malaise (stage I).
TREVISAN, GIUSTO +2 more
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Ultraviolet A1 phototherapy for the treatment of localized scleroderma
Journal of dermatology (Print), 2020Ultraviolet (UV)A1 phototherapy is effective for T‐cell‐mediated skin diseases such as atopic dermatitis and mast cell‐mediated skin diseases such as mastocytoma. UVA1 phototherapy is also effective against the sclerotic lesions of systemic sclerosis and
T. Furuhashi +5 more
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