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Primary sclerosing cholangitis. [PDF]

Translational Gastroenterology and Hepatology, 2021
Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic liver disease characterized by inflammatory destruction of the intrahepatic and/or extrahepatic bile ducts, leading to bile stasis, fibrosis, and ultimately to cirrhosis, and often ...
A. Rabiee, M. Silveira
semanticscholar   +3 more sources

Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis

Nature Communications, 2023
The genetic basis of primary sclerosing cholangitis has only been partially uncovered. Here, the authors perform a multitrait genome-wide association study to provide insight into the genetic etiology of primary sclerosing cholangitis risk and possible ...
Younghun Han, Jinyoung Byun, Catherine Zhu, Ryan Sun, Julia Y. Roh, Heather J. Cordell, Hyun-Sung Lee, Vikram R. Shaw, Sung Wook Kang, Javad Razjouyan, Matthew A. Cooley, Manal M. Hassan, Katherine A. Siminovitch, Trine Folseraas, David Ellinghaus, Annika Bergquist, Simon M. Rushbrook, Andre Franke, Tom H. Karlsen, Konstantinos N. Lazaridis, The International PSC Study Group, Katherine A. McGlynn, Lewis R. Roberts, Christopher I. Amos   +23 more
doaj   +2 more sources

Secondary sclerosing cholangitis: an unusual presentation of leptospirosis [PDF]

Tropical Medicine and Health
Sclerosing cholangitis is a rare progressive cholestatic disease that is classified as secondary sclerosing cholangitis when it is caused by an identifiable cause.
Tilan Aponso, W. M. D. A. S. Wanninayake, I. P. Wijesinghe, Nethma Jayasekara, Waruna Iddamalgoda, W. M. M. A. Wanasinghe   +5 more
doaj   +2 more sources

British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis

Gut, 2019
These guidelines on the management of primary sclerosing cholangitis (PSC) were commissioned by the British Society of Gastroenterology liver section. The guideline writing committee included medical representatives from hepatology and gastroenterology ...
Michael Huw Chapman, Gideon Hirschfield, Stephen P Pereira   +2 more
exaly   +2 more sources

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nature Microbiology, 2019
Nobuhiro Nakamoto, Wataru Suda, Po-sung Chu   +2 more
exaly   +2 more sources

Progressive cholestasis and associated sclerosing cholangitis are frequent complications of COVID‐19 in patients with chronic liver disease

Hepatology, 2022
Cholestasis is associated with disease severity and worse outcome in COVID‐19. Cases of secondary sclerosing cholangitis (SSC) after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection have been described.
L. Hartl, Katharina Haslinger, Martin Angerer, G. Semmler, M. Schneeweiss-Gleixner, M. Jachs, B. Simbrunner, D. Bauer, E. Eigenbauer, R. Strassl, M. Breuer, O. Kimberger, D. Laxar, K. Lampichler, E. Halilbasic, A. Stättermayer, A. Ba-Ssalamah, M. Mandorfer, B. Scheiner, T. Reiberger, M. Trauner   +20 more
semanticscholar   +1 more source

Primary sclerosing cholangitis [PDF]

Canadian Journal of Gastroenterology, 2008
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the bile ducts, resulting in end-stage liver disease and reduced life expectancy. PSC primarily affects young and middle-aged men, often in association with underlying inflammatory bowel disease.
Marina G Silveira, Keith D Lindor
openaire   +5 more sources

Risks of colorectal cancer and biliary cancer according to accompanied primary sclerosing cholangitis in Korean patients with ulcerative colitis: a nationwide population-based study [PDF]

Intestinal Research, 2023
Background/Aims We conducted a nationwide population-based study to investigate incidence rates of colorectal and biliary cancers according to accompanying primary sclerosing cholangitis in Korean ulcerative colitis patients.
Eun Hye Oh, Ye-Jee Kim, Minju Kim, Seung Ha Park, Tae Oh Kim, Sang Hyoung Park   +5 more
doaj   +1 more source

AASLD Practice Guidance on Primary Sclerosing Cholangitis and Cholangiocarcinoma.

Hepatology, 2022
Pathogenesis of PSC. The current model of the pathogenesis of PSC involves four major themes on a background of underlying genetic and environmental risk factors.
C. Bowlus, L. Arrivé, A. Bergquist, M. Deneau, L. Forman, S. Ilyas, K. Lunsford, Mercedes Martinez, Gonzalo Sapisochin, R. Shroff, J. Tabibian, D. Assis   +11 more
semanticscholar   +1 more source

Primary sclerosing cholangitis with partial steroid responsiveness: a case report

Fujita Medical Journal, 2023
A 69-year-old woman suspected to have IgG4-related sclerosing cholangitis causing bile duct stenosis was transferred from another hospital after diarrhea, eosinophilia, and eosinophilic infiltration were detected and prednisolone was prescribed ...
Satoshi Yamamoto, Kazuo Inui, Yoshiaki Katano, Hironao Miyoshi, Kenji Notohara   +4 more
doaj   +1 more source