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Primary Sclerosing Cholangitis [PDF]

Medicine, 1984
Primary sclerosing cholangitis (PSC) is a chronic, cholestatic liver disease caused by diffuse inflammation and fibrosis that can involve the entire biliary tree. The progressive pathological process obliterates intrahepatic and extrahepatic bile ducts, leading ultimately to biliary cirrhosis, portal hypertension and hepatic failure.
Rolland E. Dickson, Nicholas F. LaRusso, Russell H. Wiesner   +2 more
  +11 more sources

Primary sclerosing cholangitis [PDF]

Radiology, 1971
Summary The literature on the subject of sclerosing cholangitis is reviewed. The value of conserving the gall bladder, of operative cholangiography and of the administration of steroids in the management of these patients is emphasized.
L. F. Tinckler
  +11 more sources

Secondary sclerosing cholangitis: mimics of primary sclerosing cholangitis

Abdominal Radiology, 2022
Sclerosing cholangitis is a chronic cholestatic disease characterized by stricturing, beading, and obliterative fibrosis of the bile ducts. Sclerosing cholangitis is considered primary (PSC) if no underlying etiology is identified or secondary (SSC) if ...
D. Ludwig, Mark A. Anderson, M. Itani, Kedar G. Sharbidre, N. Lalwani, R. Paspulati   +5 more
semanticscholar   +3 more sources

Secondary sclerosing cholangitis: an unusual presentation of leptospirosis [PDF]

Tropical Medicine and Health
Sclerosing cholangitis is a rare progressive cholestatic disease that is classified as secondary sclerosing cholangitis when it is caused by an identifiable cause.
Tilan Aponso, W. M. D. A. S. Wanninayake, I. P. Wijesinghe, Nethma Jayasekara, Waruna Iddamalgoda, W. M. M. A. Wanasinghe   +5 more
doaj   +2 more sources

Primary sclerosing cholangitis. [PDF]

Translational Gastroenterology and Hepatology, 2021
Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic liver disease characterized by inflammatory destruction of the intrahepatic and/or extrahepatic bile ducts, leading to bile stasis, fibrosis, and ultimately to cirrhosis, and often ...
A. Rabiee, M. Silveira
semanticscholar   +4 more sources

Fine-mapping and molecular characterisation of primary sclerosing cholangitis genetic risk loci [PDF]

Nature Communications
Genome-wide association studies of primary sclerosing cholangitis have identified 23 susceptibility loci. The majority of these loci reside in non-coding regions of the genome and are thought to exert their effect by perturbing the regulation of nearby ...
Elizabeth C. Goode, Laura Fachal, Nikolaos Panousis, Loukas Moutsianas, Rebecca E. McIntyre, Benjamin Yu Hang Bai, Norihito Kawasaki, Alexandra Wittmann, Tim Raine, Simon M. Rushbrook, Carl A. Anderson   +10 more
doaj   +2 more sources

IgG4-Related Sclerosing Cholangitis and Primary Sclerosing Cholangitis

Gut and Liver, 2019
Sclerosing cholangitis (SC) is defined as a condition with progressive stenosis and destruction of the bile ducts due to diffuse inflammation and fibrosis and currently includes three categories: primary sclerosing cholangitis (PSC), secondary ...
Atsushi Tanaka
doaj   +4 more sources

Primary sclerosing cholangitis [PDF]

Canadian Journal of Gastroenterology, 2008
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the bile ducts, resulting in end-stage liver disease and reduced life expectancy. PSC primarily affects young and middle-aged men, often in association with underlying inflammatory bowel disease.
Marina G. Silveira, Keith D. Lindor
  +11 more sources

Progressive cholestasis and associated sclerosing cholangitis are frequent complications of COVID‐19 in patients with chronic liver disease

Hepatology, 2022
Cholestasis is associated with disease severity and worse outcome in COVID‐19. Cases of secondary sclerosing cholangitis (SSC) after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection have been described.
L. Hartl, Katharina Haslinger, Martin Angerer, G. Semmler, M. Schneeweiss-Gleixner, M. Jachs, B. Simbrunner, D. Bauer, E. Eigenbauer, R. Strassl, M. Breuer, O. Kimberger, D. Laxar, K. Lampichler, E. Halilbasic, A. Stättermayer, A. Ba-Ssalamah, M. Mandorfer, B. Scheiner, T. Reiberger, M. Trauner   +20 more
semanticscholar   +1 more source

AASLD Practice Guidance on Primary Sclerosing Cholangitis and Cholangiocarcinoma.

Hepatology, 2022
Pathogenesis of PSC. The current model of the pathogenesis of PSC involves four major themes on a background of underlying genetic and environmental risk factors.
C. Bowlus, L. Arrivé, A. Bergquist, M. Deneau, L. Forman, S. Ilyas, K. Lunsford, Mercedes Martinez, G. Sapisochin, R. Shroff, J. Tabibian, D. Assis   +11 more
semanticscholar   +1 more source