Results 171 to 180 of about 106,721 (360)
Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis.
Journal of Hepatology, 2021 M. Reich, L. Spomer, C. Klindt, Katharina Fuchs, J. Stindt, K. Deutschmann, J. Höhne, E. Liaskou, J. Hov, T. Karlsen, U. Beuers, J. Verheij, Sofía Ferreira-González, G. Hirschfield, S. Forbes, C. Schramm, I. Esposito, D. Nierhoff, P. Fickert, C. Fuchs, M. Trauner, María García-Beccaria, G. Gabernet, S. Nahnsen, Jan-Philipp Mallm, M. Vogel, K. Schoonjans, Tobias Lautwein, K. Köhrer, D. Häussinger, T. Luedde, M. Heikenwalder, V. Keitel +32 moresemanticscholar +1 more sourceExcluding Ascites From the GEMA‐Na Score Does Not Impact Outcome Predictions in Liver Transplant Candidates
Liver International, Volume 46, Issue 3, March 2026.ABSTRACT Background and Aims
Although GEMA‐Na outperforms MELD 3.0 for liver allocation, concerns about the subjectivity of its ascites component persist. We compared the performance of a GEMA‐Na iteration that excludes ascites with other allocation scores.Manuel Luis Rodríguez‐Perálvarez, Antonio Manuel Gómez‐Orellana, Avik Majumdar, Geoffrey W. McCaughan, María Kalafateli, Rhiannon Taylor, Gloria de la Rosa, María Victoria Aguilera, Mikel Gastaca, Carmen Cepeda‐Franco, María Luisa Ortiz, Jordi Colmenero, Alejandra Otero, Rocío González Grande, Alba Cachero, Esther Molina Pérez, Mónica Barreales, Rosa Martín Mateos, María Rodríguez‐Soler, Mario Romero, Cristina Dopazo, Carmen Alonso Martín, Elena Otón, Luisa González Diéguez, María Dolores Espinosa, Ana Arias Milla, Gerardo Blanco Fernández, Sara Lorente, Antonio Cuadrado Lavín, Miguel Sogbe, David Guijo‐Rubio, César Hervás Martínez, Emmanuel Tsochatzis +32 morewiley +1 more sourceEfficacy, Safety and Tolerability of Volixibat, an IBAT Inhibitor, in Patients With Intrahepatic Cholestasis of Pregnancy
Liver International, Volume 46, Issue 3, March 2026.ABSTRACT
Intrahepatic cholestasis of pregnancy (ICP) presents with cholestatic pruritus, elevated sBA and increased risk of adverse perinatal outcomes. Volixibat is a minimally absorbed IBAT inhibitor that interrupts enterohepatic recirculation. We describe four patients with ICP with pruritus and sBA > ULN treated with volixibat (20 or 80 mg BID ...Caroline Ovadia, Sophia Stone, Baha Sibai, Tiago Nunes, Douglas B. Mogul, Jayshree Krishnaswami, Jennifer Kahng, Furong Li, Qurratul Ann Warsi, Elaine Chien, Pamela Vig, Catherine Williamson +11 morewiley +1 more sourceIGFBP4 is a Metric for Primary Biliary Cholangitis and Attenuates Biliary Epithelial Cell Injury
Liver International, Volume 46, Issue 3, March 2026.ABSTRACT Background and Aims
Immune‐mediated bile duct injury is the primary histological feature of autoimmune cholestatic liver diseases. Macrophages, the most abundant immune cell population in the liver, have been postulated to play a critical role in biliary repair. However, it is unclear whether activated macrophages interact with injured biliary Xing Zhou, Shuyu Shao, Danning Yang, Ziyan Cheng, Toshihiro Tanaka, Patrick S. C. Leung, Koichi Tsuneyama, Aftab A. Ansari, William M. Ridgway, Pietro Invernizzi, Christopher L. Bowlus, M. Eric Gershwin, Weici Zhang +12 morewiley +1 more sourcePrimary (AL) Amyloidosis Following COVID‐19 Infection: A Case Report
Clinical Case Reports, Volume 14, Issue 2, February 2026.ABSTRACT
Primary (AL) amyloidosis is a rare systemic disorder caused by extracellular deposition of monoclonal immunoglobulin light chains, resulting in multi‐organ dysfunction. SARS‐CoV‐2 infection may induce persistent inflammatory and immune dysregulation, potentially promoting amyloid formation, although clinical evidence is limited, making the ...Nasrin Gholami, Sepideh Tahsini Tekantapeh, Amirreza Khalaji, Babak Nejati, Gholamrez Ravaei +4 morewiley +1 more sourceWas Motorized Spiral Enteroscopy Too Risky? A Systematic Review and Meta‐Analysis Including German Registry Data
United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.ABSTRACT Background and Study Aims
Motorized spiral enteroscopy (MSE) was introduced as a major advancement in small‐bowel enteroscopy, enabling higher complete enteroscopy rates with shorter procedure times. However, after a fatal adverse event (AE) involving severe esophageal injury, the device was withdrawn from the market in July 2023.Ingo Steinbrück, Armin Kuellmer, Siegbert Faiss, Hendrik Buchholz, Björn Lewerenz, Daniel Fitting, Felix Wiedbrauck, Stephan Hollerbach, Arthur Schmidt, Johannes Wilhelm Rey, Martha M. Kirstein, Franz‐Ludwig Dumoulin, Fabian Maximilian Wittich, Andreas Wannhoff, Jürgen Pohl, Matthias Friesicke, Viktor Rempel, Hans‐Peter Allgaier, Christian Wiessner, Thomas Rösch +19 morewiley +1 more sourcePrediction of Hepatocellular Carcinoma and Other Liver‐Related Events in Chronic Hepatitis B Patients With Metabolic Dysfunction or Metabolic Dysfunction‐Associated Steatotic Liver Disease
Alimentary Pharmacology &Therapeutics, Volume 63, Issue 3, Page 374-382, February 2026.This study evaluated the performance of the PAGE‐B score in HCC risk among CHB patients with metabolic dysfunction or MASLD. The PAGE‐B score effectively stratified HCC risk in both MASLD and non‐MASLD patients, especially in those without cirrhosis, where low scores were linked to negligible 5‐year HCC risk. ABSTRACT Introduction
Metabolic dysfunction Lesley A. Patmore, Ivana Carey, Jordan J. Feld, Willem P. Brouwer, Keyur Patel, Maria Buti, Pieter Honkoop, Douwe F. Postma, Hans Blokzijl, Özgur. M. Koc, Eva van Oorschot, Kosh Agarwal, Marc van der Valk, Faydra I. Lieveld, Mai Kilany, Matthijs Kramer, Joep de Bruijne, Mark A. A. Claassen, Bettina E. Hansen, Robert A. de Man, Harry L. A. Janssen, R. Bart Takkenberg, Milan J. Sonneveld +22 morewiley +1 more sourceAnti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis
, 2016 Sebastian Torben Jendrek, Daniel Gotthardt, Thomas Nitzsche, Laila Widmann, Tobias Korf, Maike Anna Michaels, Karl-Heinz Weiss, Evaggelia Liaskou, Mette Vesterhus, Tom H. Karlsen, Swantje Mindorf, Peter Schemmer, Florian Bär, Bianca Teegen, Torsten Schröder, Marc Ehlers, Christoph M. Hammers, Lars Komorowski, Hendrik Lehnert, Klaus Fellermann, Stefanie Derer, Johannes R. Hov, Christian Sina +22 moreopenalex +2 more sources