Results 11 to 20 of about 106,721 (360)

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk [PDF]

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +2 more sources

Primary Sclerosing Cholangitis Associated with Severe Ulcerative Colitis in a Young Woman: Case Report

Journal of Ardabil University of Medical Sciences, 2019
Background: Primary sclerosing cholangitis is a rare and progressive cholestatic disease characterized by narrowing of the biliary tract. Despite high levels of ulcerative colitis, early diagnosis of primary sclerosing cholangitis before the diagnosis of
Somaieh Matin, yousef Imani Marani, Hossein Salehzadeh   +2 more
doaj   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Primary Biliary Cholangitis and Primary Sclerosing Cholangitis: Current Knowledge of Pathogenesis and Therapeutics

Biomedicines, 2022
Cholangiopathies encompass various biliary diseases affecting the biliary epithelium, resulting in cholestasis, inflammation, fibrosis, and ultimately liver cirrhosis.
Ji-won Park, Jung-Hee Kim, Sung-Eun Kim, J. Jung, M. Jang, S. Park, Myung‐Seok Lee, H. Kim, K. Suk, D. J. Kim   +9 more
semanticscholar   +1 more source

Autoimmune biliary diseases: primary biliary cholangitis and primary sclerosing cholangitis

Pathologica, 2021
Summary Autoimmune cholestatic liver diseases are rare hepato-biliary disorders characterized by a progressive, inflammatory destruction of bile ducts.
S. Sarcognato, D. Sacchi, F. Grillo, N. Cazzagon, L. Fabris, M. Cadamuro, I. Cataldo, C. Covelli, A. Mangia, M. Guido   +9 more
semanticscholar   +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

Impact on follow‐up strategies in patients with primary sclerosing cholangitis

Liver international (Print), 2022
Evidence for the benefit of scheduled imaging for early detection of hepatobiliary malignancies in primary sclerosing cholangitis (PSC) is limited.
A. Bergquist, T. Weismüller, C. Levy, C. Rupp, D. Joshi, J. Nayagam, A. Montaño-Loza, E. Lytvyak, E. Wunsch, P. Milkiewicz, R. Zenouzi, C. Schramm, N. Cazzagon, A. Floreani, Ingalill Friis Liby, M. Wiestler, H. Wedemeyer, Taotao Zhou, C. Strassburg, E. Rigopoulou, G. Dalekos, Manasa Narasimman, X. Verhelst, H. Degroote, M. Vesterhus, A. Kremer, Bennet Bündgens, F. Rorsman, E. Nilsson, K. Jørgensen, Erik von Seth, Martin Cornillet, N. Nyhlin, H. Martin, S. Kechagias, K. Wiencke, Mårten Werner, B. Terziroli Beretta‐Piccoli, M. Marzioni, H. Isoniemi, J. Arola, A. Wefer, J. Söderling, M. Färkkilä, H. Lenzen   +44 more
semanticscholar   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]

, 2020
In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Alpini, Gianfranco, Francis, Heather, Kennedy, Lindsey, Kundu, Debjyoti, Meadows, Vik   +4 more
core   +1 more source

Secondary sclerosing cholangitis as cause of persistent jaundice in patients with severe COVID‐19

Liver international (Print), 2021
Little is known about cholestasis, including its most severe variant secondary sclerosing cholangitis (SSC), in critically ill patients with coronavirus disease 19 (COVID‐19). In this study, we analysed the occurrence of cholestatic liver injury and SSC,
S. Bütikofer, Daniela Lenggenhager, P. D. Wendel Garcia, E. Maggio, M. Haberecker, C. Reiner, Gregor Brüllmann, P. Buehler, C. Gubler, B. Müllhaupt, C. Jüngst, B. Morell   +11 more
semanticscholar   +1 more source