Results 191 to 200 of about 106,721 (360)
Single‐Cell Genetic Mapping of Gasdermin Expression Across Immune‐Mediated Inflammatory Diseases
The FASEB Journal, Volume 40, Issue 1, 15 January 2026.This figure illustrates the lineage‐specific causal effects of gasdermin (GSDM) expression on the risk of eight immune‐mediated inflammatory diseases (IMIDs). The analysis, based on single‐cell genetic data, shows how GSDMA, GSDMB, and GSDMD affect disease risk in various immune cell types, highlighting distinct protective or risk‐enhancing roles in ...
Xin Gao +3 more
wiley +1 more source
Genotype–phenotype interaction in Alzheimer's disease immune activation
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract INTRODUCTION Alzheimer's disease (AD) is a neurodegenerative disorder influenced by genetic factors, particularly related to immune activation. This study examines genotype‐phenotype interactions affecting immune responses in AD as a reaction to neurodegeneration.
Stephanie Knudtzon +18 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.Depression is common in AIH patients and is associated with an elevated cirrhosis risk. AIH patients with depression, mice colonized with MDD microbiota, and ConA‐treated mice subjected to CUMS exhibit intestinal barrier dysfunction and hepatic NLRP3 inflammasome overactivation.
Simin Zhou +15 more
wiley +1 more source
Protocol for the development of a core outcome set for clinical trials in primary sclerosing cholangitis [PDF]
Nasir Hussain +16 more
openalex +1 more source
Food Frontiers, Volume 7, Issue 1, January 2026.In this study, we found that based on the AHR/NF‐κB signaling pathway, IAA has a positive effect on the prevention and treatment of intestinal barrier function and also exhibits immunological activity. ABSTRACT Impairment of intestinal barrier function is intricately linked to intestinal inflammation.
Qiaoyu Sun +5 more
wiley +1 more source
Liver transplantation for sclerosing cholangitis in a polytraumatized patient [PDF]
, 2008 Andreas A. Schnitzbauer +6 more
openalex +1 more source
Systemic sclerosis associated with primary sclerosing cholangitis and hyperthyroidism: a case report
, 2023 Ali Ghassa +3 more
openalex +1 more source
How to Conduct Impactful and Sustainable Clinical Research in IBD: A Toolbox for Researchers
JCC Plus, Volume 1, Issue 1, January 2026.ABSTRACT Inflammatory bowel disease (IBD) research faces critical challenges, including underrepresentation of diverse populations and orphan phenotypes, as well as trial designs that often prioritise narrow eligibility over real‐world applicability.
Julien Kirchgesner +12 more
wiley +1 more source
The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.Abstract Many patients with inflammatory bowel disease (IBD) do not adequately respond to infliximab, potentially due to individual differences in pharmacokinetics (PK). This study aimed to identify clinical and biochemical variables associated with infliximab PK.
Ilse A. Pool +6 more
wiley +1 more source