Results 211 to 220 of about 680,317 (306)

Elastomeric 3D‐Printed Microenvironments Enable Nanonewton Force Measurements in Healthy and Diseased Human Pluripotent Stem Cell‐Derived Neuroepithelial Cells

Advanced Materials, EarlyView.
We present elastomeric three‐dimensional (3D) microstructures fabricated via two‐photon polymerization (2PP) and post‐processed through wet etching, for quantifying nanonewton (nN)‐scale forces applied by healthy and diseased neural cells. The mechanically characterized free‐standing beam architectures enable measurement of traction forces of ...
Pieter F. J. van Altena, Lucia Castillo Ransanz, Ruben H. Guis, Giulia Bergamaschi, Nanne J. Paauw, Urs Staufer, Vivi M. Heine, Angelo Accardo   +7 more
wiley   +1 more source

Diagnostic value of the kappa free light chain index in multiple sclerosis under the 2024 CSF positivity criterion: a multicentre study in oligoclonal band-negative patients. [PDF]

Front Immunol
Ferraro D, Fiore A, Di Sabatino E, Cavalla P, Gallo A, Calabrese M, Radelli M, Clerici VT, Pinardi F, Malucchi S, Portaccio E, Ragonese P, Nicoletti CG, Cordioli C, Guaschino C, Clerico M, Nociti V, Cocco E, Gallina V, Gasperini C, Solaro C, Di Filippo M.   +21 more
europepmc   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Identifying predictors of systemic sclerosis-associated interstitial lung disease: A two-decade analysis of clinical and radiologic characteristics. [PDF]

Medicine (Baltimore)
Alnaimat F, Al-Halaseh S, Ismail O, Fateh M, Allouzi S, Almallah A, Adwan MH, Qasem U, Al Oweidat K, Samara OA, Mustafa KN.   +10 more
europepmc   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

Spider-MS: an individualized polyhedral prediction of multiple sclerosis prognosis. [PDF]

Brain
Tur C, Susin-Calle S, Otero-Romero S, Carvajal R, Carbonell-Mirabent P, Cobo-Calvo Á, Roos I, Arévalo MJ, Ariño H, Arrambide G, Auger C, Castilló J, Comabella M, Elosua I, Galán I, Masot-Llima A, Midaglia L, Mongay-Ochoa N, Nos C, Pappolla A, Pareto D, Río J, Rodríguez-Acevedo B, Saez de Gordoa E, Vidal-Jordana Á, Vilaseca A, Zabalza A, Rovira À, Sastre-Garriga J, Kalincik T, Montalban X, Tintoré M.   +31 more
europepmc   +1 more source

Bottom‐Up Engineering of a Human Neuromuscular System for Modeling Activity‐Induced Remodeling, Metabolic Stress, and Endothelial‐Modulated Excitability

Advanced Materials, EarlyView.
Using a bottom‐up approach, we engineered a human neuromuscular microchip to investigate distinct adaptive responses to neural stimulation and metabolic stress. Further integration of endothelial cells revealed their critical role in modulating neuromuscular excitability, establishing a comprehensive neurovascular‐muscular model.
Jinchul Ahn, Min‐seop Kim, Ju‐Hee Kim, Seok‐Hyeon Kang, Dain Lee, Hui‐Wen Liu, Seung‐cheol Shin, Kyuhwan Na, Yesl Jun, Oak‐Kee Hong, Ji Hun Yang, Jin‐A Kim, Hwanseok Jang, Hong Nam Kim, Roger D. Kamm, Ji‐Hoon Kim, Jang‐Won Son, Seok Chung   +17 more
wiley   +1 more source

Prevalence of Slowly Expanding Lesions in Patients With Multiple Sclerosis: A Systematic Review and Meta-Analysis. [PDF]

Neurology
Liampas A, Artemiadis A, Tseriotis VS, Prados F, Preziosa P, Calvi A, Hadjigeorgiou G, Rocca MA, Filippi M, Ciccarelli O.   +9 more
europepmc   +1 more source

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

Endothelial and platelet dysfunction in systemic sclerosis with pulmonary hypertension. [PDF]

PLoS One
Imerbtham T, Sriwantana T, Ngamjanyaporn P, Sotananusak T, Ngammisri P, Trerayapiwat K, Dumrongkitchaiporn P, Pisitkun P, Srihirun S, Vivithanaporn P, Sibmooh N.   +10 more
europepmc   +1 more source