Results 241 to 250 of about 680,317 (306)

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Protective effect of Glycyrrhizin on cuprizone-induced model of multiple sclerosis in male C57BL/6 mice. [PDF]

IBRO Neurosci Rep
Morakkabi AS, Hassanpour S, Hosseini R.
europepmc   +1 more source

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

Investigating the role of serum IL-6 in predicting outcomes of b-cell depleting therapy in multiple sclerosis: a retrospective cohort study. [PDF]

BMC Neurol
Kölsche T, Hagler R, Huntemann N, Masanneck L, Müller M, Kutsojannis BJ, Boeckers JM, Kirschner P, Schulze-Bosse K, Aktas O, Meuth SG, Ruck T, Pawlitzki M.   +12 more
europepmc   +1 more source

Multiple sclerosis

Biomedical Journal, 2014
openaire   +3 more sources

Interleukin-40 in Systemic Sclerosis: A Treatment-Sensitive Marker of Immune Modulation Rather Than Disease Activity. [PDF]

Clin Transl Sci
Vasi İ, Bağrıaçık EÜ, Kardaş RC, Örüklü N, Yaman M, Yıldırım D, Kaya B, Duran R, Karaduman İ, Çakır İY, Küçük H, Göker B, Erden A, Öztürk MA.   +13 more
europepmc   +1 more source

Juvenile Systemic Sclerosis in a Single Center: Clinical Features, Capillaroscopic Findings, Immunological Profile, and Treatment Outcomes-A Retrospective Descriptive Analysis. [PDF]

Children (Basel)
Osminina M, Podzolkova V, Berezhanskiy P, Podchernyaeva N, Volnukhin V, Ermolinskiy P, Chebysheva S, Kuzina M, Afonina E, Kostina Y, Soboleva V, Aseeva E, Moldon P, Puvaneswaran V, Geppe N.   +14 more
europepmc   +1 more source

Multiple sclerosis as an under-recognized cause of acute vertigo: clinical and pathophysiologic insights. [PDF]

Front Neurol
Anagnostou E, Kouvli M.
europepmc   +1 more source

Selective associations between cognitive practice effects and reactive balance adaptation in multiple sclerosis. [PDF]

Arch Clin Neuropsychol
Hall MJC, Stevenson L, Davidson R, Macerlane S, Mulvihill E, McIntyre F, Cuttle S, Peterson DS, Monaghan AS.   +8 more
europepmc   +1 more source