Results 161 to 169 of about 1,941 (169)

Cloning and expression study of the mouse tetrodotoxin-resistant voltage-gated sodium channel alpha subunit NaT/Scn11a.

Biochemical and Biophysical Research Communications, 2000
We have cloned a tetrodotoxin-resistant (TTX-R) voltage-gated sodium channel alpha subunit from a mouse cDNA library and designated it as NaT. It encodes 1765 amino acid residues and is virtually identical to that of Scn11a, which has been reported recently, except for 40 nt and 14 aa substitutions.
K. Ogata, S. Jeong, H. Murakami, H. Hashida, T. Suzuki, N. Masuda, M. Hirai, K. Isahara, Y. Uchiyama, J. Goto, I. Kanazawa   +10 more
semanticscholar   +3 more sources

EP88 THE GAIN-OF-FUNCTION R222S VARIANT IN SCN11A CONTRIBUTES TO VISCERAL HYPERALGESIA AND INTESTINAL DYSMOTILITY IN SAN11AR222S/R222S MICE

Gastroenterology
Chenyu Zhao, Jishuo Jin, Haoye Hu, Xi Zhou, Xiaoliu Shi   +4 more
semanticscholar   +2 more sources

Primary erythermalgia as a sodium channelopathy: screening for SCN9A mutations: exclusion of a causal role of SCN10A and SCN11A. [PDF]

Archives of Dermatology, 2008
To elucidate the rate of missense mutations in the SCN9A gene (which encodes sodium channel Na(v)1.7) (OMIM 603415) among patients with primary erythermalgia and to examine the possibility that other sodium channels can cause the disease.Case series.Department of Medicine, Radboud University Nijmegen, the Netherlands.Six patients with sporadic and 9 ...
J. Drenth, R. T. te Morsche, S. Mansour, P. Mortimer   +3 more
semanticscholar   +4 more sources

Structure of the sodium channel gene SCN11A

Molecular Neurobiology, 2002
Exon/intron boundaries in the regions encoding the trans-membrane segments of voltage-gated Na channel genes are conserved, supporting their proposed evolution from a single domain channel, while the exons encoding the cytoplasmic loops are less conserved with their evolutionary heritage being less defined.
S. Dib-Hajj, L. Tyrrell, S. Waxman
semanticscholar   +3 more sources

A Case Report of Familial Episodic Pain Syndrome Type 3 in a 5-Year-Old Boy

Journal of Clinical and Nursing Research
Medical history summary: The child has suffered from episodic joint pain in the lower extremities since childhood, with occurrences ranging from 1 to 3 times daily, predominantly during rainy, cold, and humid weather, as well as in the afternoons and ...
Tianyi Hu, Minghao Li
semanticscholar   +1 more source

The Evolving Landscape of Small Fiber Neuropathy

Seminars in neurology
Small fiber neuropathy (SFN) belongs to a heterogeneous group of disorders in which thinly myelinated Aδ and unmyelinated C-fibers are primarily affected, leading to neuropathic pain and autonomic symptoms.
G. Devigili, R. Lombardi, G. Lauria, D. Cazzato   +3 more
semanticscholar   +1 more source

A case of familial episodic pain syndrome with SCN11A mutation treated prophylactically with sodium channel blockers

, 2019
F. Tanaka, T. Goto, E. Ogawa, S. Moriyama, Asami Ito, K. Kurosawa, K. Kosaki   +6 more
semanticscholar   +1 more source

Altered NaV1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction.

The Journal of General Physiology
Noortje W M van den Braak, Samuel Kuehs, G. Z. Peschke, B. Namer, A. Lischka, K. Eggermann, C. Dumke, Vishal Sudha Bhagavath Eswaran, S. Nikolin, J. Weis, J. Schulz, Angelika Lampert, Ingo Kurth, R. Rolke, Enrico Leipold, Maike F. Dohrn   +15 more
semanticscholar   +1 more source

Identification of Axonal Regeneration-Related Genes and a Potential Analgesic Drug for Neuropathic Pain

Molecular Neurobiology
Yang Liu, Yongxue Zhang, Shikang Hao, Yabin Shi, Xiaoyue Chen, Zhibin Ye, Guona Zheng, Lin Kang, Han Hao   +8 more
semanticscholar   +1 more source