Mechanical allodynia triggered by cold exposure in mice with the Scn11a p.R222S mutation: a novel model of drug therapy for neuropathic pain related to NaV1.9 [PDF]
Naunyn-Schmiedeberg's Archives of Pharmacology, 2020 Mutations within the SCN11A gene which encodes the voltage-gated sodium channel NaV1.9 mainly expressed in small fiber sensory neurons have been associated with neuropathic disorders; however, suitable medications have not been fully investigated.
Yosuke Matsubara +4 more
semanticscholar +3 more sources
Dynamic changes in the microRNA expression profile reveal multiple regulatory mechanisms in the spinal nerve ligation model of neuropathic pain. [PDF]
PLoS ONE, 2011 Neuropathic pain resulting from nerve lesions or dysfunction represents one of the most challenging neurological diseases to treat. A better understanding of the molecular mechanisms responsible for causing these maladaptive responses can help develop ...
David von Schack +18 more
doaj +6 more sources
Genomics, 1999 Previous studies have shown that sodium channel alpha-subunit NaN is preferentially expressed in small-diameter sensory neurons of dorsal root ganglia and trigeminal ganglia.
S. Dib-Hajj +5 more
semanticscholar +3 more sources
Persistent (Na v 1.9) sodium currents in human dorsal root ganglion neurons. [PDF]
PainNav1.9 is of interest to the pain community for a number of reasons, including the human mutations in the gene encoding Nav1.9, SCN11a, that are associated with both pain and loss of pain phenotypes.
Zhang X, Hartung JE, Gold MS.
europepmc +2 more sources
Effect of Single Nucleotide Polymorphism in SCN9A, SCN10A and SCN11A Genes on Postoperative Pain
Turkish Endodontic Journal, 2022 N. Akbıyık
semanticscholar +3 more sources
A Family of Infantile Episodic Limb Pain with a SCN11A Gene Mutation
Nihon Naika Gakkai Zasshi, 2022 Nagie Tosaki +9 more
semanticscholar +2 more sources
Broadening the Genetic Spectrum of Painful Small-Fiber Neuropathy through Whole-Exome Study in Early-Onset Cases [PDF]
Int J Mol SciSmall-Fiber Neuropathy (SFN) is a disorder of the peripheral nervous system, characterised by neuropathic pain; approximately 11% of cases are linked to variants in Voltage-Gated Sodium Channels (VGSCs).
Misra K +13 more
europepmc +3 more sources
The parabss1 Drosophila melanogaster as Model for Chronic Nociception: Insights Into Cannabidiol Analgesic Effects. [PDF]
Eur J PainABSTRACT Background Chronic pain, which is often unrelated to ongoing injury, is poorly understood and difficult to treat. Genetic studies have identified voltage‐gated sodium (Nav) channels, particularly gain‐of‐function mutations such as L858F and R1150W in human NaV1.7, as involved in the development of chronic pain. Methods A chronic pain model was
Malta SM +7 more
europepmc +2 more sources
Gain-of-function mutations in SCN11A cause familial episodic pain. [PDF]
The American Journal of Human Genetics, 2013 Many ion channel genes have been associated with human genetic pain disorders. Here we report two large Chinese families with autosomal-dominant episodic pain. We performed a genome-wide linkage scan with microsatellite markers after excluding mutations in three known genes (SCN9A, SCN10A, and TRPA1) that cause similar pain syndrome to our findings ...
X. Zhang +19 more
semanticscholar +3 more sources
A Systematic Review of Congenital Insensitivity to Pain, a Rare Disease [PDF]
J Pers MedIntroduction: Pain perception, far from being a pathological mechanism, is a crucial protective stimulus to prevent additional injuries. Any disturbance in this complex system poses significant risks to individuals, affecting their quality of life and ...
Rodríguez-Blanque R +6 more
europepmc +3 more sources