Results 61 to 70 of about 1,941 (169)

Additional file 1 of SCN11A gene deletion causes sensorineural hearing loss by impairing the ribbon synapses and auditory nerves

, 2021
Additional file 1: Figure S1. The expression of Nav1.9 is located in spiral bundles beneath the IHCs bases. A, Horizontal section showing Nav1.9 (red) in the afferent endings and in the afferent radial fibers leading through the FN (arrow). B, Cross section showing Nav1.9 (red) labeling afferent radial fibers leading through the FN (arrow).
Zu, Mian, Guo, Wei-Wei, Cong, Tao, Ji, Fei, Zhang, Shi-Li, Zhang, Yue, Song, Xin, Sun, Wei, He, David Z. Z., Shi, Wei-Guo, Yang, Shi-Ming   +10 more
openaire   +2 more sources

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. [PDF]

, 2015
Bipolar disorder is a complex neuropsychiatric disorder that is characterized by intermittent episodes of mania and depression; without treatment, 15% of patients commit suicide.
, Alda, Martin, Boyer, Leah, Brennand, Kristen J., Calabrese, Joseph R., Diffenderfer, Kenneth E., Eames, Tameji, Gage, Fred H., Kelsoe, John R., Kim, Yongsung, Marchetto, Maria C., McCarthy, Michael J., Mertens, Jerome, Mi, Shuangli, Nievergelt, Caroline M., Nurnberger, John I., Oedegaard, Ketil J., Pham, Son, Schafer, Simon T., Soltani, Sheila, Wang, Qiu-Wen, Yang, Bo, Yao, Jun, Yu, Diana X., Zandi, Peter P., Zhang, Jian, Zheng, Yi   +26 more
core   +1 more source

Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes. [PDF]

, 2015
In the peripheral sensory nervous system the neuronal expression of voltage-gated sodium channels (Navs) is very important for the transmission of nociceptive information since they give rise to the upstroke of the action potential (AP).
Abdulla, Abrahamsen, Abriel, Abriel, Abriel, Abriel, Akopian, Akopian, Akopian, Aley, Aley, Amaya, Arévalo, Bair, Basbaum, Battaini, Ben-Johny, Bendahhou, Beneski, Bennett, Bennett, Berta, Bierhaus, Bierhaus, Bird, Bird, Biswas, Black, Black, Black, Bongiorno, Bouhassira, Bretin, Brouwer, Brower, Brüggemann, Cachemaille, Campbell, Cang, Cantrell, Cantrell, Casals-Diaz, Catterall, Catterall, Cesare, Cesare, Chahine, Chatelier, Chattopadhyay, Chen, Chen, Cheng, Chi, Ciechanover, Coggeshall, Cohen, Costa, Costa, Coward, Coward, Cox, Cronin, Cummins, Cummins, Cummins, Cusdin, Daemen, Dascal, Decosterd, Deribe, Deschênes, Deval, Dib-Hajj, Dib-Hajj, Dib-Hajj, Dib-Hajj, Dib-Hajj, Dietrich, Dina, Dina, Djouhri, Dogrul, Dong, Duan, Dubin, Dustrude, Edinger, Ednie, England, Errington, Errington, Faber, Faber, Fahmi, Ferrari, Ferreira, Ferreira, Fertleman, Firsov, Fitzgerald, Fjell, Fotia, Fotia, Fukuoka, Fukuoka, Galan, Gasser, Gaudet, Gee, Gershon, Gold, Gold, Gold, Goldin, Gould, Gudes, Han, Heikamp, Henry, Herzog, Herzog, Hirade, Hiruma, Ho, Hockley, Hoeijmakers, Hoeijmakers, Huang, Hucho, Hudmon, Hunter, Ikeda, Inagaki, Isom, Isom, Isom, James, Jarecki, Jarvis, Ji, Ji, Jin, Joazeiro, Johnson, Johnson, Joshi, Julius, Kazarinova-Noyes, Kazen-Gillespie, Kerr, Khasar, Khasar, Khasar, Kim, Kispersky, Klugbauer, Kreegipuu, Kresge, Kress, Kretschmer, Kruger, Laedermann, Laedermann, Laedermann, Laedermann, Lai, Latremoliere, Leipold, Leo, Leung, Li, Liang, Liu, Liu, Liu, Liu, Liu, Lolignier, Lopez-Santiago, Lopez-Santiago, Lou, Luo, Luo, Maingret, Malhotra, Malhotra, Maltsev, Mann, Mao, Matzner, Matzner, Messner, Metzger, Millan, Minett, Mittmann, Moon, Moremen, Morgan, Mori, Murphy, Murray, Nagasako, Narayanan, Nassar, Nelson, Noda, Novella, Numann, Nuss, Obata, Olsson, Payandeh, Perry, Persson, Pertin, Petho, Pickart, Pierre, Pitchford, Plummer, Priest, Qu, Rang, Ranscht, Raymond, Recio-Pinto, Ren, Renganathan, Renganathan, Ritchie, Rossie, Rossier, Rush, Rush, Rush, Sadamasu, Sangameswaran, Sanna, Schaller, Schepelmann, Schild, Schirmeyer, Schmidt, Schmidt, Scholz, Shah, Shao, Shi, Shih, Smith, Smith, Snyder, Snyder, Solà, Souza, Stamboulian, Staub, Strickland, Stucky, Sun, Suter, Taiwo, Tan, Thakor, Theriault, Thornalley, Toledo-Aral, Toledo-Aral, Tong, Toth, Turk, Tyrrell, van Bemmelen, Vanoye, Vijayaragavan, Vijayaragavan, Vijayaragavan, von Hehn, Wada, Wada, Waechter, Wang, Waxman, Waxman, Waxman, Waxman, Way, Wells, Widmann, Woolf, Woolf, Woolf, Woolf, Woolf, Wu, Xu, Xu, Xu, Xu, Yan, Yanagita, Yanagita, Yang, Yeomans, Yin, Young, Yu, Yu, Yuhi, Zhang, Zhang, Zhang, Zhang, Zhou, Zhou, Zhuang, Zimmer, Zochodne   +318 more
core   +2 more sources

An exercise-only intervention in obese fathers restores glucose and insulin regulation in conjunction with the rescue of pancreatic islet cell morphology and microRNA expression in male offspring [PDF]

, 2017
Published: 9 February 2017Paternal obesity programs metabolic syndrome in offspring. Low-impact exercise in obese males improves the metabolic health of female offspring, however whether this occurred in male offspring remained unknown.
Fullston, T., Lane, M., McPherson, N., Owens, J., Sandeman, L.   +4 more
core   +3 more sources

Gene expression changes in the ventral hippocampus and medial prefrontal cortex of adolescent alcohol-preferring (P) rats following binge-like-alcohol drinking [PDF]

, 2017
Binge drinking of alcohol during adolescence is a serious public health concern with long-term consequences, including decreased hippocampal and prefrontal cortex volume and defects in memory.
Bell, Richard L., Ding, Zheng-Ming, Edenberg, Howard J., Liu, Yunlong, McBride, William J., McClintick, Jeanette N., Xuei, Xiaoling   +6 more
core   +1 more source

Polygenic risk score and prostate specific antigen predict death from prostate cancer in men with intermediate aggressive cancer

International Journal of Cancer, EarlyView.
What's New? Using 21 SNPs, two novel PRS were constructed and used to develop two new machine‐learning classifiers, one for the detection of prostate cancer and the other for the prediction of its aggressiveness and subsequent mortality. The classifier for disease detection is built using the PRS as the sole feature, whereas the one for disease ...
Leandro Rodrigues Santiago, Efthymios Ladoukakis, Dorota Scibior‐Bentkowska, Belinda Nedjai   +3 more
wiley   +1 more source

Sudden unexpected death in genetic epileptic encephalopathies: a role of neurocardiac genes

Эпилепсия и пароксизмальные состояния, 2018
It is well known that sudden unexpected death in epilepsy (SUDEP) is one of the most significant factors of mortality in epileptic patients. There is an increased risk of SUDEP in genetic epileptic encephalopathies (EE), partly because those syndromes ...
E. D. Belousova, M. A. Shkolnikova
doaj   +1 more source

Induced Proprioceptor and Low‐Threshold Mechanoreceptor Neurons Derived from Human Pluripotent Stem Cells Exhibit Distinct Functional Mechanosensory Properties

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This study describes derivation of two distinct mechanosensory subpopulations from human pluripotent stem cells using a transcription factor mediated approach. Of significance, functional interrogation of induced mechanosensory subtypes reveal their unique responses to mechanical stimulation in the absence of end‐organs.
Amy J. Hulme, Rocio K. Finol‐Urdaneta, Jeffrey R. McArthur, Nicholas R. Marzano, Simon Maksour, Amarinder Thind, Yang Guo, Dominic Kaul, Marnie Maddock, Oliver Friedrich, Boris Martinac, David J. Adams, Mirella Dottori   +12 more
wiley   +1 more source

Regenerating the Senses: Stem Cell‐Derived Sensory Neurons and Functional Genomics in Neurological Disorders

Sensory Neuroscience, Volume 1, Issue 3, December 2025.
ABSTRACT Sensory neuron disorders, such as peripheral neuropathies and trigeminal neuralgia, cause chronic pain and sensory dysfunction; however, regenerative treatments are limited. Human pluripotent stem cells (hPSCs) provide a powerful platform to model these diseases by generating functional sensory neuron subtypes, including nociceptors and ...
Pushpanathan Muthuirulan, Avanthika Nityanand, Anjali Pandit, Vaishnavi Gururajan   +3 more
wiley   +1 more source

Gene duplications and evolution of vertebrate voltage-gated sodium channels [PDF]

, 2006
Author Posting. © The Author(s), 2006. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution.
A Amores, A Meyer, A Sidow, AE Novak, AL George Jr, AL Goldin, AL Goldin, Alicia E. Novak, Alison D. Taylor, AN Akopian, AN Akopian, Angeles B. Ribera, B Venkatesh, C Fried, C Jozefowicz, CW Tsai, DL Swofford, DM Krzemien, DW Stock, E Tzoumaka, F Amaya, F Ausubel, FSJ Souza de, GF Lopreato, H Piontkivska, HA Hartmann, Harold H. Zakon, J Dhar Malhotra, J Sambrook, J Wittbrodt, JAA Nylander, JD Thompson, JP Huelsenbeck, JS Trimmer, K Vandepoele, KD Crow, KL Schaller, L Sangameswaran, LG Lundin, LM Donahue, LU Sneddon, M Westerfield, Manda C. Jost, N Suzuki, NA Hukriede, NW Plummer, NW Plummer, P Fatt, PF Stadler, PW Holland, Q Wang, RB Rogart, S Hagiwara, S Hoegg, S Ohno, SC Ekker, SD Dib-Hajj, SD Dib-Hajj, SK Maier, T Zimmer, V Prince, VA Souslova, WA Catterall, WP Maddison, Ying Lu   +64 more
core   +1 more source