Results 71 to 80 of about 1,941 (169)

Peripheral temperature dysregulation associated with functionally altered Na V 1.8 channels [PDF]

, 2023
The voltage-gated sodium channel Na V 1.8 is prominently expressed in the soma and axons of small-caliber sensory neurons, and pathogenic variants of the corresponding gene SCN10A are associated with peripheral pain and autonomic dysfunction.
Heinemann, Stefan H., Kuehs, Samuel, Kurth, Ingo, Leipold, Enrico, Lischka, Annette, Loose, Simon, Nau, Carla   +6 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

Role of NaV1.9 in inflammatory mediator‐induced activation of mouse airway vagal C‐fibres

Journal of Physiology, 2023
The influence of NaV1.9 on inflammatory mediator‐induced activation of airway vagal nodose C‐fibres was evaluated by comparing responses in wild‐type versus NaV1.9‐/‐ mice. A single‐cell RT‐PCR analysis indicated that virtually all nodose C‐fibre neurons
Joyce S. Kim, Hui Sun, S. Meeker, B. Undem   +3 more
semanticscholar   +1 more source

Detecting Convergence of Amino Acid Physicochemical Properties Underlying the Organismal Adaptive Convergent Evolution

Molecular Ecology Resources, Volume 25, Issue 8, November 2025.
ABSTRACT Many studies have proposed various comparative genomic methods to probe the molecular basis for adaptive functional convergence between species, conventionally by detecting the convergence of amino acid states between orthologous protein sequences of these species or lineages.
Shanshan Chen, Zhengting Zou
wiley   +1 more source

Homozygosity for the SCN10A Polymorphism rs6795970 Is Associated With Hypoalgesic Inflammatory Bowel Disease Phenotype

Frontiers in Medicine, 2018
Background: Hypoalgesic inflammatory bowel disease (IBD), a condition in which patients with active disease do not perceive and/or report abdominal pain, is associated with serious complications and there is a lack of cost-effective, reliable diagnostic ...
Eugene Gonzalez-Lopez, Yuka Imamura Kawasawa, Vonn Walter, Lijun Zhang, Walter A. Koltun, Xuemei Huang, Kent E. Vrana, Matthew D. Coates   +7 more
doaj   +1 more source

Complementary Roles of DNA Methylation and miRNA in Regulating Gene Expression Under Environmental Stress in Biological Invasions

Evolutionary Applications, Volume 18, Issue 11, November 2025.
ABSTRACT Biological invasions significantly threaten global biodiversity and disrupt the stability of ecosystems worldwide. Effective responses to environmental stressors are crucial for invasion success; however, the underlying epigenetic regulatory mechanisms remain poorly understood, especially regarding the interplay among multiple regulatory ...
Weijie Yan, Ruiying Fu, Xuena Huang, Aibin Zhan   +3 more
wiley   +1 more source

Expansion of voltage-dependent Na+ channel gene family in early tetrapods coincided with the emergence of terrestriality and increased brain complexity [PDF]

, 2010
Author Posting. © The Authors, 2010. This is the author's version of the work. It is posted here by permission of Oxford University Press for personal use, not for redistribution.
Akopian, Angelino, Blomme, Caldwell, Clack, Cummins, Cummins, Dehal, Dib-Hajj, Dorward, Duflocq, Farré, Glenner, Goldin, Hains, Harold H. Zakon, Hasenstaub, Hedges, Hellsten, Herzog, Hill, Hoegg, Hu, Hunt, Hurley, Jackson, Jarnot, Kellis, Kuraku, Lopreato, Lorincz, Madsen, Maeda, Maier, Manda C. Jost, Meyer, Milinkovitch, Northcutt, Novak, Ogiwara, Okamura, Panopoulou, Piontkivska, Plummer, Proske, Ross, Saito, Sallan, Schmidt-Hieber, Shedlock, Sneddon, Sneddon, Soares, van Wart, von Düring, Watanabe, Westenbroek, Whitaker, Whitaker, Ying Lu   +59 more
core   +2 more sources

Diffusion Tensor Imaging Reveals Altered Centrality of Pain‐Related Regions in SCN9A‐Associated Small Fiber Neuropathy

Journal of Neuroimaging, Volume 35, Issue 6, November/December 2025.
ABSTRACT Background and Purpose Small fiber neuropathy (SFN) is a neuropathic disorder that is associated with chronic pain. While most SFN cases are idiopathic, SFN can also have hereditary causes. For example, rare SCN9A gene mutations can impair the NaV1.7 sodium channel, which leads to dorsal root ganglion neuron hyperexcitability, causing SFN ...
Gerhard S. Drenthen, Dennis Kool, Amir Far, Jaymin Upadhyay, David E. J. Linden, Raquel van Gool, Celine P. Goijen, Ingemar S. J. Merkies, Walter H. Backes, Catharina G. Faber, Jacobus F. A. Jansen, Janneke G. J. Hoeijmakers   +11 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2015/16:Voltage-gated ion channels [PDF]

, 2015
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org),
,, Alexander, Stephen Ph, Benson, Helen E, Catterall, William A, Davies, Jamie A, Faccenda, Elena, Kelly, Eamonn, Marrion, Neil, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +4 more sources

Genetics and genomics in postoperative pain and analgesia [PDF]

, 2018
Purpose of reviewThe review describes recent advances in genetics and genomics of postoperative pain, the association between genetic variants and the efficacy of analgesics, and the role of pharmacogenomics in the selection of appropriate analgesic ...
Kalso, Eija, Kaunisto, Mari A., Palada, Vinko   +2 more
core   +1 more source