Results 81 to 90 of about 1,941 (169)

Die Chemie und Biologie der Tetrodotoxin Naturstofffamilie

Angewandte Chemie, Volume 137, Issue 35, August 25, 2025.
Tetrodotoxin ist vor allem als das Gift des Kugelfisches bekannt, einer Delikatesse in der japanischen Küche. Seine Toxizität beruht auf der selektiven Blockade von NaV Kanälen, wie am Beispiel der NaV1.7 Pore dargestellt, wobei das DEKA Motiv hervorgehoben ist, das für die Durchlässigkeit von Natriumionen verantwortlich ist.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

Familial Episodic Pain Syndromes

Journal of Pain Research, 2022
Yu Shen,1 Yilei Zheng,1 Daojun Hong1,2 1Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, People’s Republic of China; 2Department of Medical Genetics, The First Affiliated Hospital of Nanchang University ...
Shen Y, Zheng Y, Hong D
doaj  

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.
Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7 pore, highlighting the DEKA motif, which permeates sodium ions.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

Na+ current expression in human atrial myofibroblasts: identity and functional roles [PDF]

, 2014
In the mammalian heart fibroblasts have important functional roles in both healthy conditions and diseased states. During pathophysiological challenges, a closely related myofibroblast cell population emerges, and can have distinct and significant roles ...
Colleen Kondo, Darrell Belke, Jussi T. Koivumäki, Mary M. C. Maleckar, Paul W. M. Fedak, Robert B. Clark, Wayne R. Giles   +6 more
core   +2 more sources

A Novel Function of NaV Channel β3 Subunit in Endothelial Cell Alignment Through Autophagy Modulation

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
NaVβ3 expression is increased by laminar shear stress (LSS) through KLF4 induction (1). NaVβ3 is retained within the cell and interacts with mTOR protein and colocalizes partially with LAMP1 and LC3B, lysosome and autophagosome markers, respectively (2). Since SiRNA SCN3B induces the decrease of LC3B expression and cell alignment in response to LSS (3),
Léa Réthoré, Anne‐Laure Guihot, Linda Grimaud, Coralyne Proux, Benjamin Barré, François Guillonneau, Catherine Guette, Alice Boissard, Cécile Henry, Jérôme Cayon, Rodolphe Perrot, Daniel Henrion, Christian Legros, Claire Legendre   +13 more
wiley   +1 more source

Ion channel expression in human melanoma samples. in silico identification and experimental validation of molecular targets [PDF]

, 2019
Expression of 328 ion channel genes was investigated, by in silico analysis, in 170 human melanoma samples and controls. Ninety-one members of this gene-family (i.e., about 28%) show a significant (p 0.90 and p 90% in most cases).
D’Arcangelo, Daniela, Facchiano, Antonio, Facchiano, Francesco, Giampietri, Claudia, Marchetti, Paolo, Scatozza, Francesca   +5 more
core   +1 more source

Painful stimulation increases functional connectivity between supplementary motor area and thalamus in patients with small fibre neuropathy

European Journal of Pain, Volume 29, Issue 2, February 2025.
Abstract Background The lead symptom of small fibre neuropathy (SFN) is neuropathic pain. Recent functional magnetic resonance imaging (fMRI) studies have indicated central changes in SFN patients of different etiologies. However, less is known about brain functional connectivity during acute pain processing in idiopathic SFN. Methods We conducted fMRI
Sebastian Scheliga, Maike F. Dohrn, Thilo Kellermann, Angelika Lampert, Roman Rolke, Barbara Namer, Greta Z. Peschke, Nortje van den Braak, Annette Lischka, Marc Spehr, Han‐Gue Jo, Ute Habel   +11 more
wiley   +1 more source

Identification of Eight Histone Methylation Modification Regulators Associated With Breast Cancer Prognosis

IET Systems Biology, Volume 19, Issue 1, January/December 2025.
This study developed a risk scoring model based on histone methylation modification regulators (HMMRs) to assess their role in breast cancer (BRCA) prognosis and drug sensitivity. The model, constructed using LASSO regression, identified eight key HMMRs associated with survival, which showed independent predictive values. Immune and functional analyses
Yan‐Ni Cao, Xiao‐Hui Li, Xing‐Jie Chen, Kang‐Cheng Xu, Jun‐Yuan Zhang, Hao Lin, Yu‐Xian Liu   +6 more
wiley   +1 more source

A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for {beta} subunit interaction [PDF]

, 2004
A mutation in the sodium channel SCN1A was identified in a small Italian family with dominantly inherited generalized epilepsy with febrile seizures plus (GEFS+).
Aradi, I., Benna, P., de Haan, G, Escayg, A., Goldin, A. L., Isom, L. L., Kearney, J. A., Levin, S. I., MacDonald, B. T., McEwen, D. P., Meisler, M. H., Montalenti, E., Soltesz, I., Spampanato, J.   +13 more
core   +1 more source

Characterization of a novel heterozygous variant in the histidyl‐tRNA synthetase gene associated with Charcot–Marie–Tooth disease type 2W

IUBMB Life, Volume 76, Issue 12, Page 1125-1138, December 2024.
Abstract Heterozygous pathogenic variants in the histidyl‐tRNA synthetase (HARS) gene are associated with Charcot–Marie–Tooth (CMT) type 2W disease, classified as an axonal peripheral neuropathy. To date, at least 60 variants causing CMT symptoms have been identified in seven different aminoacyl‐tRNA synthetases, with eight being found in the catalytic
Sarah D. P. Wilhelm, Angelica A. Moresco, Alberto D. Rivero, Victoria Mok Siu, Ilka U. Heinemann   +4 more
wiley   +1 more source