Results 111 to 120 of about 5,273 (196)

Cis‐acting allele specific expression (ASE) differences induced by alcohol and impacted by sex as well as parental genotype of origin [PDF]

, 2018
Background Alcohol use disorders (AUDs) are influenced by complex interactions between the genetics of the individual and their environment. We have previously identified hundreds of polygenic genetic variants between the selectively bred high and low ...
Bell, Richard L., Liang, Tiebing, Lo, Chiao-Ling, Lossie, Amy C., Lumeng, Lawrence, Muir, Williams M., Zhou, Feng C.   +6 more
core   +1 more source

Analgesia linked to Nav1.7 loss of function requires µ- and δ-opioid receptors [version 1; referees: 2 approved]

Wellcome Open Research, 2018
Background: Functional deletion of the Scn9a (sodium voltage-gated channel alpha subunit 9) gene encoding sodium channel Nav1.7 makes humans and mice pain-free. Opioid signalling contributes to this analgesic state.
Vanessa Pereira, Queensta Millet, Jose Aramburu, Cristina Lopez-Rodriguez, Claire Gaveriaux-Ruff, John N. Wood   +5 more
doaj   +1 more source

Modulation of Ion Channels in the Superior Cervical Ganglion Neurons by Myocardial Ischemia and Fluvastatin Treatment

Frontiers in Physiology, 2018
Background: The superior cervical ganglion (SCG) of the autonomic nervous system plays an important role in different cardiovascular diseases.
Lijun Cheng, Xinghua Wang, Tong Liu, Gary Tse, Gary Tse, Huaying Fu, Guangping Li   +6 more
doaj   +1 more source

Therapeutic opportunities for targeting cold pain pathways [PDF]

, 2015
Cold pain is a frequent symptom in neuropathic pain. Compared to other pain modalities, such as heat pain, the mechanisms behind physiological and pathological cold pain remain elusive.
Lewis, Richard J., Vetter, Irina, Yin, Kathleen, Zimmermann, Katharina   +3 more
core   +1 more source

Primary erythromelalgia caused by SCN9A gene mutation: A case report and literature review

Pifu-xingbing zhenliaoxue zazhi
Objective To report a case of hereditary skin disease mainly characterized by burning pain of the lower legs and feet, accompanied by flush and elevated skin temperature, and to identify the pathogenic genes and mutation sites in order to explore ...
Cuicui SUN, Sai YANG, Hang ZHENG, Yunsheng LIANG, Zhimiao LIN, Yongfeng CHEN   +5 more
doaj   +1 more source

Paroxysmal extreme pain disorder M1627K mutation in human Na_v1.7 renders DRG neurons hyperexcitable

Molecular Pain, 2008
Background Paroxysmal extreme pain disorder (PEPD) is an autosomal dominant painful neuropathy with many, but not all, cases linked to gain-of-function mutations in SCN9A which encodes voltage-gated sodium channel Nav1.7.
Tyrrell Lynda, Jarecki Brian W, Estacion Mark, Dib-Hajj Sulayman D, Fischer Tanya Z, Lawden Mark, Cummins Theodore R, Waxman Stephen G   +7 more
doaj   +1 more source

Pan-cancer ion transport signature reveals functional regulators of glioblastoma aggression

The EMBO Journal
Ion channels, transporters, and other ion-flux controlling proteins, collectively comprising the “ion permeome”, are common drug targets, however, their roles in cancer remain understudied.
Alexander T Bahcheli, Hyun-Kee Min, Masroor Bayati, Hongyu Zhao, Alexander Fortuna, Weifan Dong, Irakli Dzneladze, Jade Chan, Xin Chen, Kissy Guevara-Hoyer, Peter B Dirks, Xi Huang, Jüri Reimand   +12 more
doaj   +1 more source

Identification of key genes and pathways involved in response to pain in goat and sheep by transcriptome sequencing

Biological Research, 2018
Purpose This aim of this study was to investigate the key genes and pathways involved in the response to pain in goat and sheep by transcriptome sequencing.
Xiuling Deng, Dong Wang, Shenyuan Wang, Haisheng Wang, Huanmin Zhou   +4 more
doaj   +1 more source

Dendritikus sejt altípusok együttműködése fiziológiás és kóros állapotban = The interplay of dendritic cell subtypes in health and disease [PDF]

, 2011
A dendritikus sejtek (DC) az immunfolyamatok fontos irányítói, melyek alapvető szerepet játszanak a központi és perifériás tolerancia és a gyulladásos folyamatok kiváltásában, fenntartásában és szabályozásában.
Benkő, Szilvia, Bácsi, Attila, Gogolák, Péter, Kis-Tóth (Ludányi), Katalin, Lányi, Árpád, Rajnavölgyi, Éva, Réthi, Bence, Szabó, Attila, Varga, Alíz, Veréb, Zoltán   +9 more
core  

Complex management of a patient with refractory primary erythromelalgia lacking a SCN9A mutation.

Journal of pain research, 2017
A 41-year-old woman presented with burning and erythema in her extremities triggered by warmth and activity, which was relieved by applying ice. Extensive workup was consistent with adult-onset primary erythromelalgia (EM). Several pharmacological treatments were tried including local anesthetics, capsaicin, ziconotide, and dantrolene, all providing 24-
Low,Sarah, Robbins,Wendye, Tawfik,Vivianne   +2 more
openaire   +4 more sources