Results 31 to 40 of about 5,273 (196)

A Review of the Therapeutic Targeting of SCN9A and Nav1.7 for Pain Relief in Current Human Clinical Trials

Journal of Pain Research, 2023
Anton Dormer,1 Mahesh Narayanan,1 Jerome Schentag,1 Daniel Achinko,1 Elton Norman,1 James Kerrigan,2 Gary Jay,2 William Heydorn2 1Research and Development, Pepvax, Inc, Silver Spring, MD, USA; 2Research and Development, Navintus, Inc, Princeton, NJ ...
Dormer A, Narayanan M, Schentag J, Achinko D, Norman E, Kerrigan J, Jay G, Heydorn W   +7 more
doaj  

Association of small-fiber polyneuropathy with three previously unassociated rare missense SCN9A variants

Canadian Journal of Pain, 2020
Background: Small fiber polyneuropathy (SFN) involves ectopic firing and degeneration of small-diameter, somatic/autonomic peripheral axons. Causes include diabetes, inflammation and rare pathogenic mutations, including in SCN9-11 genes that encode small
Mary A. Kelley, Anne Louise Oaklander
doaj   +1 more source

Clinical features for diagnosis and management of patients with PRDM12 congenital insensitivity to pain. [PDF]

, 2016
BACKGROUND: Congenital insensitivity to pain (CIP) is a rare extreme phenotype characterised by an inability to perceive pain present from birth due to lack of, or malfunction of, nociceptors.
Ahmed, Mushtaq, Bennett, Christopher, Chen, Ya-Chun, Sharif, Saghira Malik, Sheridan, Eamonn, Valente, Enza-Maria, Woods, Geoffrey, Zhang, Stella   +7 more
core   +3 more sources

Functional confirmation that the R1488* variant in SCN9A results in complete loss-of-function of Nav1.7

BMC Medical Genetics, 2018
Background Individuals with an extremely rare inherited condition, termed Congenital Insensitivity to Pain (CIP), do not feel pain in response to noxious stimuli.
Wen He, Gareth T. Young, Baohong Zhang, Peter J. Cox, Lily Ting-Yin Cho, Sally John, Sara A. Paciga, Linda S. Wood, Nicolas Danziger, Serena Scollen, Ciara Vangjeli   +10 more
doaj   +1 more source

Neuropathologic Damage Induced by Radiofrequency Ablation at Different Temperatures – An Experimental Study

BioMedica, 2021
Background and Objective: Radiofrequency ablation (RFA) is a safe and less invasive technique that uses an electric current to damage nerve tissue to stop it from sending pain signals.
Li Su, Yu Dong, Ying Chen, Baoguo Yao, Peng Song, Ruiting Xu, Rui Li, Ping Liu, Yu Zhang, Li Mu, Xin Tong, Linwei Ma, Jianjun Yu   +12 more
doaj   +1 more source

Episodic neurologic disorders: syndromes, genes, and mechanisms. [PDF]

, 2013
Many neurologic diseases cause discrete episodic impairment in contrast with progressive deterioration. The symptoms of these episodic disorders exhibit striking variety.
Fu, Ying-Hui, Ptáček, Louis J, Russell, Jonathan F   +2 more
core   +2 more sources

Infrequent SCN9A mutations in congenital insensitivity to pain and erythromelalgia [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2012
Mutations in SCN9A have been reported in (1) congenital insensitivity to pain (CIP); (2) primary erythromelalgia; (3) paroxysmal extreme pain disorder; (4) febrile seizures and recently (5) small fibre sensory neuropathy. We sought to investigate for SCN9A mutations in a clinically well-characterised cohort of patients with CIP and erythromelalgia.We ...
Klein, Christopher J, Wu, Yanhong, Kilfoyle, Dean H, Sandroni, Paola, Davis, Mark D, Gavrilova, Ralitza H, Low, Phillip A, Dyck, Peter J   +7 more
openaire   +2 more sources

Regulation of Nav1.7: A Conserved SCN9A Natural Antisense Transcript Expressed in Dorsal Root Ganglia.

PLoS ONE, 2015
The Nav1.7 voltage-gated sodium channel, encoded by SCN9A, is critical for human pain perception yet the transcriptional and post-transcriptional mechanisms that regulate this gene are still incompletely understood.
Jennifer Koenig, Robert Werdehausen, John E Linley, Abdella M Habib, Jeffrey Vernon, Stephane Lolignier, Niels Eijkelkamp, Jing Zhao, Andrei L Okorokov, C Geoffrey Woods, John N Wood, James J Cox   +11 more
doaj   +1 more source

Genetics update: monogenetics, polygene disorders and the quest for modifying genes [PDF]

, 2018
The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships.
Symonds, Joseph D., Zuberi, Sameer M.
core   +1 more source

Genetic polymorphisms of SCN9A are associated with oxaliplatin-induced neuropathy [PDF]

BMC Cancer, 2017
Oxaliplatin is a chemotherapy agent active against digestive tumors. Peripheral neuropathy is one of the most important dose-limiting toxicity of this drug. It occurs in around 60-80% of the patients, and 15% of them develop severe neuropathy. The pathophysiology of oxaliplatin neurotoxicity remains unclear.
Sereno, María, Gutiérrez Gutiérrez, Gerardo, Moreno Rubio, Juan, Apellániz Ruiz, María, Sánchez Barroso, Lara, Casado, Enrique, Falagan, Sandra, López Gómez, Miriam, Merino, María, Gómez Raposo, César, Rodriguez Salas, Nuria, Zambrana Tébar, Francisco, Rodríguez Antona, Cristina   +12 more
openaire   +6 more sources