Results 41 to 50 of about 5,273 (196)
Case Reports in Neurological Medicine, 2016 Objective. To describe the use of an advanced genetic testing technique, whole exome sequencing, to diagnose a patient and their family with a SCN9A channelopathy. Setting. Academic tertiary care center. Design. Case report. Case Report.
Ashley Cannon +3 more
doaj +1 more source
Expression and Physiology of Voltage-Gated Sodium Channels in Developing Human Inner Ear
Frontiers in Neuroscience, 2021 Sodium channel expression in inner ear afferents is essential for the transmission of vestibular and auditory information to the central nervous system.
Rikki K. Quinn +14 more
doaj +1 more source
Systematic review and meta-analysis of genetic risk factors for neuropathic pain [PDF]
, 2018 Neuropathic pain (NP) is an increasingly common chronic pain state and a major health burden, affecting approximately 7-10% of the general population. Emerging evidence suggests that genetic factors could partially explain individual susceptibility to NP
Hébert, Harry L. +4 more
core +2 more sources
No cure, no care? Diagnostic and therapeutic challenges in rare neuropathic pain syndromes
Journal of Affective Disorders Reports, 2023 body: Children, who are born without any perception of pain, tend to develop a severe phenotype of self-injury. Pain, despite being a dreadful experience, is an important warning signal that prevents us from cutting, biting, or burning ourselves ...
Maike F. Dohrn +3 more
doaj +1 more source
Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief [PDF]
, 2016 INTRODUCTION: Chronic pain is a massive clinical problem. We discuss the potential of subtype selective sodium channel blockers that may provide analgesia with limited side effects.
Emery, EC, Luiz, AP, Wood, JN
core +1 more source
Trigeminal neuralgia - diagnosis and treatment [PDF]
, 2017 Introduction Trigeminal neuralgia (TN) is characterized by touch-evoked unilateral brief shock-like paroxysmal pain in one or more divisions of the trigeminal nerve. In addition to the paroxysmal pain, some patients also have continuous pain.
Bendtsen, Lars +3 more
core +1 more source
Voltage-gated sodium channels in taste bud cells
BMC Neuroscience, 2009 Background Taste bud cells transmit information regarding the contents of food from taste receptors embedded in apical microvilli to gustatory nerve fibers innervating basolateral membranes.
Williams Mark E +8 more
doaj +1 more source
Pain behavior in SCN9A (Nav1.7) and SCN10A (Nav1.8) mutant rodent models
Neuroscience Letters, 2021 The two voltage gated sodium channels Nav1.7 and Nav1.8 are expressed in the peripheral nervous system and involved in various pain conditions including inflammatory and neuropathic pain. Rodent models bearing deletions or mutations of the corresponding genes, Scn9a and Scn10a, were created in order to understand the role of these channels in the ...
Xue, Yaping +3 more
openaire +4 more sources
BMC Musculoskeletal Disorders, 2012 Background A consistent line of investigation suggests that autonomic nervous system dysfunction may explain the multi-system features of fibromyalgia (FM); and that FM is a sympathetically maintained neuropathic pain syndrome.
Vargas-Alarcon Gilberto +6 more
doaj +1 more source
Parallel Evolution of Tetrodotoxin Resistance in Three Voltage-Gated Sodium Channel Genes in the Garter Snake Thamnophis sirtalis [PDF]
, 2014 Members of a gene family expressed in a single species often experience common selection pressures. Consequently, the molecular basis of complex adaptations may be expected to involve parallel evolutionary changes in multiple paralogs.
Brodie, Edmund D. +6 more
core +1 more source