Results 61 to 70 of about 5,273 (196)

Human Sensory Neuron-like Cells and Glycated Collagen Matrix as a Model for the Screening of Analgesic Compounds

Cells, 2022
Increased collagen-derived advanced glycation end-products (AGEs) are consistently related to painful diseases, including osteoarthritis, diabetic neuropathy, and neurodegenerative disorders. We have recently developed a model combining a two-dimensional
Michelle Cristiane Bufalo, Maíra Estanislau Soares de Almeida, José Ricardo Jensen, Carlos DeOcesano-Pereira, Flavio Lichtenstein, Gisele Picolo, Ana Marisa Chudzinski-Tavassi, Sandra Coccuzzo Sampaio, Yara Cury, Vanessa Olzon Zambelli   +9 more
doaj   +1 more source

Integrative single cell RNA‐sequencing and spatial transcriptomics uncovers distinct macrophage‐fibroblast cross‐talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell‐cell interactions in FAI and hip OA.
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia‐Lung Wu   +9 more
wiley   +1 more source

SCN9A rs6746030 Polymorphism and Pain Perception in Combat Athletes and Non-Athletes

Genes, 2023
One of the genes associated with pain perception is SCN9A, which encodes an α-subunit of the voltage gated sodium channel, NaV1.7, a crucial player in peripheral pain sensation. It has been suggested that a common missense polymorphism within SCN9A (rs6746030; G>A; R1150W) may affect nociception in the general population, but its effects of pain ...
Katarzyna Leźnicka, Maciej Pawlak, Marek Sawczuk, Agata Gasiorowska, Agata Leońska-Duniec   +4 more
openaire   +2 more sources

Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

BMC Neurology, 2021
Background Many antiseizure medications (ASMs) control seizures by blocking voltage-dependent sodium channels. Polymorphisms of sodium channel genes may affect the response to ASMs due to altering the effect of ASMs on blocking sodium channels.
Chih-Hsiang Lin, Chen-Jui Ho, Yan-Ting Lu, Meng-Han Tsai   +3 more
doaj   +1 more source

Оценка побочных эффектов применения ингибитора Na-Ca обменника KB-R7943 как противоболевого препарата при диабетической нейропатии у крыс

Интегративная физиология, 2023
Работа посвящена исследованию побочных эффектов применения селективного блокатора натрий-кальциевого обменника KB-R7943 как противоболевого препарата у крыс со стрептозотоцин-индуцированным сахарным диабетом 1-го типа.
Иван Борисович Сухов, Оксана Викторовна Чистякова, Любовь Владимировна Баюнова, Наталья Николаевна Шестакова   +3 more
doaj   +1 more source

Genomic Investigations Unveil the Genetic Underpinnings of Environmental Adaptation in African Goat Populations

Integrative Zoology, EarlyView.
This study integrates genomics and landscape genetics to analyze African goat environmental adaptation. Analyzing 1591 samples, it finds population structure differentiates geographically into four groups, with gene flow between wild Yura goats and North Africans.
Weifeng Peng, Yihua Wang, Yiyuan Zhang, Lei Gao, Lili Wu, Shuping Wang, Yiyang Gao, Wanlu Shi, Kaixin Lu, Rong Deng, Junting Li, Jing Han, Xiaohui Lu, Yujie Liu, Xiaojiao Tang, Yunxia Zhang, Guoyin Li, Li Huang, Mingsheng Yang, Xiaoyan Li   +19 more
wiley   +1 more source

Evaluation of behavior in transgenic mouse models to understand human congenital pain conditions [PDF]

, 2018
BACKGROUND: Containing a brain for signal processing and decision making, and a peripheral component for sensation and response, the nervous system provides higher organisms a powerful method of interacting with their environment.
Bullock, Daniel
core  

The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy [PDF]

, 2014
Sequence matching analyses show that Clostridium tetani neurotoxin shares numerous pentapeptides (68, including multiple occurrences) with 42 human proteins that, when altered, have been associated with epilepsy.
Kanduc, D., Lucchese, G., Spinosa, J.P.
core   +3 more sources

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Dravet Syndrome : A Genetic Epileptic Disorder [PDF]

, 2012
Dravet syndrome (DS), or severe myoclonic epilepsy in infancy, is one of the most severe types of genetic epilepsy. It is characterized by the initial occurrence of febrile or afebrile seizures that often evolve into status epilepticus in infants with ...
Akiyama, Mari, Kobayashi, Katsuhiro, Ohtsuka, Yoko   +2 more
core   +1 more source