Results 71 to 80 of about 85,725 (306)

FEM Simulation of Non-Progressive Growth from Asymmetric Loading and Vicious Cycle Theory: Scoliosis Study Proof of Concept [PDF]

, 2010
Scoliosis affects about 1-3% of the adolescent population, with 80% of cases being idiopathic. There is currently a lack of understanding regarding the biomechanics of scoliosis, current treatment methods can be further improved with a greater ...
Adeeb, Samer, Carey, Jason P., Fok, Jonathan W.   +2 more
core   +1 more source

A Novel Splice Variant in ERGIC1 Causes Arthrogryposis Multiplex Congenita—Characterization Using Urine‐Derived Cells

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis multiplex congenita (AMC) is defined as the presence of joint contractures affecting at least two body regions at birth. Three different ERGIC1 variants have been reported in individuals with AMC. Here, we report on a 16‐year‐old male with a homozygous ERGIC1 c.250+1G>A variant that was classified as a variant of uncertain ...
Lauren Kerr, Paul McKay, Juliana Marulanda, Zenghui Wu, Reggie Hamdy, Sena Tavukcu, Noémi Dahan‐Oliel, Frank Rauch   +7 more
wiley   +1 more source

Potential Interaction between WNT16 and Vitamin D on Bone Qualities in Adolescent Idiopathic Scoliosis Patients and Healthy Controls

Biomedicines
Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal deformity that is associated with low bone mineral density (BMD). Vitamin D (Vit-D) supplementation has been suggested to improve BMD in AIS, and its outcomes may be related to genetic ...
Guangpu (Kenneth) Yang, Huanxiong Chen, Ka-Lo Cheng, Man-Fung Tang, Yujia Wang, Lik-Hang (Alec) Hung, Chun-Yiu (Jack) Cheng, King-Lun (Kingston) Mak, Yuk-Wai (Wayne) Lee   +8 more
doaj   +1 more source

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source

Radiation-Induced Intraspinal Chondrosarcoma: A Case Report

Global Spine Journal, 2015
Study Design Case report and review of the literature. Objective To report a unique case of an intraspinal chondrosarcoma that was diagnosed 18 years after radiotherapy for a cervical carcinoma and its remarkably unusual clinical presentation.
Peter Obid MD, Mathias Vierbuchen, Eduard Wolf, Michael Reichl, Thomas Niemeyer, Hüseyin Übeyli, Alexander Richter   +6 more
doaj   +1 more source

Can intraoperative T1 tilt predict postoperative shoulder imbalance in patients with Lenke 2 adolescent idiopathic scoliosis?: a retrospective study in Japan [PDF]

Asian Spine Journal
Study Design Retrospective cohort study. Purpose To evaluate whether intraoperative changes in T1 tilt can predict the development of postoperative shoulder imbalance (PSI) in patients with Lenke type 2 adolescent idiopathic scoliosis (AIS).
Yuki Kinoshita, Yusuke Hori, Masaki Kawamura, Takashi Namikawa, Masatoshi Hoshino, Akira Matsumura   +5 more
doaj   +1 more source

Biallelic PIGB Variants Cause Motor Neuropathy with Conduction Blocks and Peripheral Nerve Hyperexcitability

Annals of Neurology, EarlyView.
Objective Glycosylphosphatidylinositol (GPI)‐anchored proteins play critical roles in nervous system function. Pathogenic variants in genes involved in GPI‐anchor biosynthesis cause early‐onset multisystem disorders known as inherited GPI deficiencies. We describe a novel neuromuscular phenotype associated with PIGB deficiency.
Gorka Fernández‐Eulate, Romain Duval, Marina Konyukh, Alessandro Bertini, Ayse Candayan, Albena Jordanova, Theresa Brunet, Wolfgang Müller‐Felber, Helena F. Pernice, Katrin Hahn, Nadja Ehmke, Juliane Beuschlein, Bertrand Isidor, Benjamin Cogné, Yann Péréon, Annabelle Chaussenot, John Rendu, Aysylu Murtazina, Dmitrii Subbotin, Artem Borovikov, Andrey Marakhonov, Chiara Pisciotta, Paola Saveri, Daniele Cazzato, Lucie Lemeray, Bérengère Koehl, Jean‐Madeleine de Sainte‐Agathe, Stefano Facchini, Ilaria Quartesan, Andrea Cortese, Yesim Parman, Arman Cakar, Davide Pareyson, Slim Azouzi, Tanya Stojkovic   +34 more
wiley   +1 more source

Full-time bracing versus hybrid bracing in adolescent idiopathic scoliosis: study protocol for a randomised controlled trial

Trials
Background Adolescent idiopathic scoliosis (AIS) is a complex three-dimensional spinal deformity affecting 2–4% of adolescents. During the peripubertal stage, untreated AIS may progress rapidly and lead to adverse outcomes such as back pain and poor body
Adam Yiu Chung Lau, Ho Man Kee, Kenneth Guangpu Yang, Eric Cheuk Kin Kwan, Alec Lik Hang Hung, Wayne Yuk Wai Lee, Man Sang Wong, Jack Chun Yiu Cheng, Tsz Ping Lam   +8 more
doaj   +1 more source

Pain assessment in patients with adolescent idiopathic scoliosis at different stages of disease evolution

, 2014
OBJECTIVE: The correlation between pain complaints and the severity of the spinal curvature in adolescent idiopathic scoliosis remains controversial. The aim of this study was to evaluate the presence and intensity of back pain in adolescent idiopathic ...
Gotfryd,Alberto Ofenhejm, Poletto,Patricia Rios, Fernando José Franzin, Patricia Rios Poletto, Luciano Miller Reis Rodrigues, Abreu,Luiz Carlos de, Valenti,Vitor E., Vitor E. Valenti, Franzin,Fernando José, Rodrigues,Luciano Miller Reis, Luiz Carlos de Abreu, Alberto Ofenhejm Gotfryd   +11 more
core   +1 more source

Pelvic Obliquity Impacts Acetabular Coverage Measurements, and the Elevated Hip Is More Frequently Symptomatic in Hip Preservation Patients

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To quantify the impact of femoral head height discrepancies on pelvic‐based versus ground‐based measurements for lateral center‐edge angle (LCEA) and Tönnis angle and to determine whether these discrepancies affected the clinical presentation of patients who presented to a hip preservation clinic.
Benjamin T. Johnson, Daniel C. Lewis, Allan K. Metz, Ashley L. Matter, Christopher L. Peters, Lucas A. Anderson, Stephen K. Aoki   +6 more
wiley   +1 more source