Results 81 to 90 of about 1,846,335 (256)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Local Interaction Density (LID), a Fast and Efficient Tool to Prioritize Docking Poses
Molecules, 2019 Ligand docking at a protein site can be improved by prioritizing poses by similarity to validated binding modes found in the crystal structures of ligand/protein complexes.
Célien Jacquemard +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Scandinavian Journal of Surgery, 2002 Severity scales to characterize the nature and extent of injury are important adjuncts to trauma care systems, trauma research and many of the elements of a complete public health approach to injury. This article provides a brief overview of severity scale development over the past 30 years during which the science to support such initiatives has ...
openaire +2 more sources
The micronucleus assay in radiation accidents [PDF]
, 2009 The cytokinesis-block micronucleus assay in peripheral blood lymphocytes is a standardised and validated technique for biodosimetry. Automated scoring of micronuclei allows large scale applications as in population triage in case of radiation accidents ...
Thierens, Hubert, Vral, Anne
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Clinical, Cosmetic and Investigational Dermatology, 2022 Sanusi Umar,1– 3 Paul Shitabata,2,4 Paul Rose,5 Marissa J Carter,6 Rattapon Thuangtong,7– 9 Boudine Lohlun,10 Hind Benhiba,11 Tayfun Oguzoglu,12 Maria Marta Zollinger,13 Juan Maldonado,14 Alejandro Gonzalez,15 Myroslava Novosilska,16 Alba G ...
Umar S +13 more
doaj
Levelling the Field through Scoring Auctions [PDF]
This paper considers how price auctions compare with two-dimensional bidding on price and quality, when bidders have comparative advantages. Two-dimensional bids are evaluated by a scoring rule decided by the auctioneer and three auction types are ...
Christensen, Eirik N.
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A Scoring Tool for Websites – A Case of Sustainable Organizations [PDF]
European Journal of Interdisciplinary Studies, 2014 This paper introduces a scoring tool to analyse company sustainability marketing efforts. We identify the expected scores for the companies selected on Corporate Responsibility Magazine’s list of 100 Best Corporate Citizens of the year.
Ahmed GOMAA +2 more
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