Results 31 to 40 of about 20,842 (245)

Straightness detection method of scraper conveyor in fully mechanized mining face based on integrated inertial navigation

Meikuang Anquan, 2022
Aiming at the problem of straightness detection of scraper conveyor in fully mechanized mining face, the straightness detecting method of a scraper conveyor based on combined inertial navigation is proposed.
YANG Bo, WU Ning
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Longitudinal torsional vibrations of the chain drive system of mine scraper conveyor

Scientific Reports, 2023
To deeply analyse the dynamic characteristics of the scraper conveyor during operation, the mechanical characteristics of the coupled longitudinal and torsional vibrational modes under excitation by cargo loading are studied.
Jinnan Lu, Runkun Yang, Jun Mao, Chunxue Xie   +3 more
doaj   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Mining Scraper Conveyors Chain Drive System Lightweight Design: Based on DEM and Topology Optimization

Computation
For the issue of excessive mass in the chain drive system of long-distance scraper conveyors, this paper proposes a method to optimize the scraper chains by integrating discrete element simulation (DEM) with topological optimization. The aim is to reduce
Qiang Zhang, Wei Liu, Anhao Jia, Shouji Sun, Xin Li, Xiangjun Song   +5 more
doaj   +1 more source

Study on load current characteristics of scraper conveyor under vertical impact

Meitan kexue jishu, 2023
During the operation of the mine scraper conveyor, it is easy to be affected by the uneven movement of hydraulic support and the uneven cutting bottom of shearer, bearing various types of impact, of which the impact in the vertical direction is the most ...
SI Lei, LI Jiahao, TAN Chao, WANG Zhongbin, LI Xiaoyu, HUO Xiaoquan, YUAN Zengyun   +6 more
doaj   +1 more source

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

Study of a Companion Trajectory Kinematics Analysis Method for the Five-Blade Rotor Swing Scraper Pump

Machines
This paper proposes a five-blade rotor swing scraper pump (FRSSP) to overcome traditional volumetric pumps’ drawbacks, such as poor sealing performance, low volumetric efficiency, and complex structure.
Chong Wang, Shigong Zhang, Tiezhu Zhang, Hongxin Zhang, Minghao Li   +4 more
doaj   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

Energy consumption optimization of scraper conveyors adopting rolling friction: A technological revolution in China’s coal mining equipment

Journal of Industrial Safety
As the core equipment of fully mechanized mining, the scraper conveyor performs the important task of coal transportation. However, the scraper conveyor often consumes excessive energy during its operation due to local friction, resulting in energy waste.
Lin Chen, Guangtong Song, Duanyi Wang, Xiaofeng Zhang, Jian Hao   +4 more
doaj   +1 more source