Results 31 to 40 of about 577 (189)

Development of a low cost screen to identify hearing loss in young children and appropriate services for deaf children in Binga, Zimbabwe [PDF]

open access: yes, 2003
There is a high prevalence of hearing loss estimated between 8 and 16% in young children in rural areas in Zimbabwe. Deaf children are usually identified late and do not benefit from early interventions.
Dube, Servious, Dube, S
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Digital Learning in Rural Ontario, Canada: An Evaluation of the Computer for Seniors Program

open access: yesJournal of Rural and Community Development, 2020
This article presents an evaluation of an educational intervention that provided computer skills training for a sample of n = 17 rural seniors in North Middlesex, Ontario, Canada.
Judith M Dunlop   +3 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Hustler dies. Permanence of stereotypes around male sex-workers on the global screen [PDF]

open access: yes, 2019
El cine y la televisión han representado audiovisualmente en numerosas ocasiones el trabajo sexual realizado por hombres, aunque no siempre respondiendo a la realidad de la profesión.
Mateos Miera, Eladio   +2 more
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Precarious Creativity: Global Media, Local Labor

open access: yes, 2016
Precarious Creativity examines the seismic changes confronting media workers in an age of globalization and corporate conglomeration. This pathbreaking anthology peeks behind the hype and supposed glamor of screen media industries to reveal the ...

core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Democracy and the media in developing countries : a case study of the Philippines [PDF]

open access: yes, 1996
This thesis examines the relationships between the Philippine media, class power and the state. It focusses particularly on the economic and political actors and agencies, including the press, which have promoted or hindered democratisation in the ...
Smith, Desmond, Smith , Desmond
core  

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