Results 11 to 20 of about 172 (171)
Practical considerations in screening for genetic alterations in cholangiocarcinoma [PDF]
Annals of Oncology, 2021 Cholangiocarcinoma (CCA) encompasses diverse epithelial tumors historically associated with poor outcomes due to an aggressive disease course, late diagnosis, and limited benefit of standard chemotherapy for advanced disease. Comprehensive molecular profiling has revealed a diverse landscape of genomic alterations as oncogenic drivers in CCA.
Bekaii-Saab, TS +2 more
openaire +3 more sources
Serological screening for cysticercosis in mentally altered individuals [PDF]
Tropical Medicine & International Health, 2002 The parasitic infection neurocysticercosis may give rise to a variety of psychiatric manifestations that resemble, but are different from, primary psychiatric disorders. The aim of this study was to determine if among individuals from a neurocysticercosis‐endemic area of Colombia who apparently had a psychiatric manifestation with associated ...
Fernando, Sanzón +10 more
openaire +2 more sources
A genome‐wide screen for copy number alterations in Aicardi syndrome [PDF]
American Journal of Medical Genetics Part A, 2009 AbstractAicardi syndrome is a severe neurodevelopmental disorder that affects females or rarely males with a 47,XXY karyotype. Therefore, it is thought to be caused by heterozygous defects in an essential X‐linked gene or by defects in an autosomal gene with sex‐limited expression. Because all reported cases are sporadic with one exception, traditional
Xiaoling, Wang +6 more
openaire +2 more sources
Timing of Newborn Blood Collection Alters Metabolic Disease Screening Performance [PDF]
Frontiers in Pediatrics, 2021 Blood collection for newborn genetic disease screening is preferably performed within 24–48 h after birth. We used population-level newborn screening (NBS) data to study early postnatal metabolic changes and whether timing of blood collection could impact screening performance. Newborns were grouped based on their reported age at blood collection (AaBC)
Gang Peng +6 more
openaire +4 more sources
Screening for Barley Mutants With Altered Hormone Sensitivity in Their Aleurone Layers [PDF]
Plant Physiology, 1980 A method, based on the diffusion assay of alpha-amylase on agar plates, was developed to screen for barley (Himalaya) mutants with altered sensitivity to gibberellic acid (GA(3)) or abscisic acid (ABA) in their aleurone layers. The seeds produced by sodium azide-mutagenized barley were screened for their ability to synthesize and secrete alpha-amylase ...
Tuan-Hua David Ho +2 more
openaire +2 more sources
A Genome-wide RNAi Screen for Polypeptides that Alter rpS6 Phosphorylation [PDF]
, 2011 Mammalian target of rapamycin (mTOR) is a giant protein kinase that controls cell proliferation, growth, and metabolism. mTOR is regulated by nutrient availability, by mitogens, and by stress, and operates through two independently regulated hetero-oligomeric complexes.
Angela, Papageorgiou, Joseph, Avruch
openaire +2 more sources
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source