Results 11 to 20 of about 658,556 (263)

To screen or not to screen [PDF]

Cancer, 2016
Screening is the early detection of a latent disorder by a test to allow early intervention with the aim of improving prognosis. Individual and population perspectives on screening are perceived as opposing interests of patients and the population. In this article, we try to reconcile these perspectives.
G. Coureau, G. Coureau, Marion Bailhache, Marion Bailhache, Simone Mathoulin-Pélissier, Simone Mathoulin-Pélissier, L. Rachid Salmi, L. Rachid Salmi   +7 more
  +9 more sources

Butyrylcarnitine Elevation in Newborn Screening: Reducing False Positives and Distinguishing between Two Rare Diseases through the Evaluation of New Ratios

Biomedicines, 2023
One of the main challenges of newborn screening programs, which screen for inherited metabolic disorders, is cutting down on false positives (FPs) in order to avoid family stresses, additional analyses, and unnecessary costs.
MariaAnna Messina, Alessia Arena, Riccardo Iacobacci, Luisa La Spina, Concetta Meli, Federica Raudino, Martino Ruggieri   +6 more
doaj   +1 more source

Acknowledgment to Reviewers of International Journal of Neonatal Screening in 2021

International Journal of Neonatal Screening, 2022
Rigorous peer-reviews are the basis of high-quality academic publishing [...]
International Journal of Neonatal Screening Editorial Office
doaj   +1 more source

Identification of active small-molecule modulators targeting the novel immune checkpoint VISTA

BMC Immunology, 2021
Background Cancer immunotherapy has gained increasing popularity as a novel approach to treat cancer. A member of the B7 family, V-domain immunoglobulin suppressor of T-cell activation (VISTA) is a novel immune checkpoint that regulates a broad spectrum ...
Ting-ting Li, Jing-wei Jiang, Chen-xin Qie, Chun-xiao Xuan, Xin-lei Hu, Wan-mei Liu, Wen-ting Chen, Jun Liu   +7 more
doaj   +1 more source

Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models

Cell Death Discovery, 2023
Palmitoylation of proteins plays important roles in various physiological processes, such as cell proliferation, inflammation, cell differentiation etc. However, inhibition of protein palmitoylation has led to few new drugs to date.
Yumeng Wang, Shujie Zhang, Huiqin He, Hongyi Luo, Yannan Xia, Yuanyuan Jiang, Jingwei Jiang, Li Sun   +7 more
doaj   +1 more source

The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke

Journal of Neuroinflammation, 2020
Background Spontaneous functional recovery occurs during the acute phase after stroke onset, but this intrinsic recovery remains limited. Therefore, exploring the mechanism underlying spontaneous recovery and identifying potential strategies to promote ...
Hao Sun, Xinran He, Xia Tao, Tingting Hou, Mingming Chen, Meijun He, Hong Liao   +6 more
doaj   +1 more source

Detection of maple toxins in mare's milk

Journal of Veterinary Internal Medicine, 2021
Background Plants from the Sapindaceae family that are consumed by horses (maple) and humans (ackee and litchi) are known to contain the toxins hypoglycin A and methylenecyclopropylglycine which cause seasonally occurring myopathy in horses and entero ...
Johannes Sander, Michael Terhardt, Nils Janzen   +2 more
doaj   +1 more source

Establishment and application of suspension static method in blood group screening of automated blood group analyzer

Scientific Reports, 2023
The accuracy of blood group identification is the basis of blood transfusion safety. In order to increase the detection rate of weak agglutination, unexpected antibodies (UAb) and blood subtypes for pre-transfusion testing, the blood group screening ...
Min Huang, Chengping Ma, Yan Li, Ruiping Dong, Rongrong Pang, Shuizhen Huang, Qiang Fu, Libo Zhang   +7 more
doaj   +1 more source

Comparison of the methods of operation of the artificial intelligence system in the ultra-high sensitivity mode for the autonomous description of chest X-rays without pathology [PDF]

Digital Diagnostics
BACKGROUND: Up to 95% of digital fluoroscopy screening studies are free of pathologic changes. Radiologists typically spend the majority of their time reviewing and describing such studies.
Evgeniy D. Nikitin, Nikita S. Plaksin, Maria B. Garetz, Evgeniy M. Gutin   +3 more
doaj   +1 more source

Sensitive screening of single nucleotide polymorphisms in cell free DNA for diagnosis of gestational tumours

npj Genomic Medicine, 2022
Tumours expressing human chorionic gonadotropin (hCG), the majority of which are difficult to biopsy due to their vascularity, have disparate prognoses depending on their origin.
Geoffrey J. Maher, Rosemary A. Fisher, Baljeet Kaur, Xianne Aguiar, Preetha Aravind, Natashia Cedeno, James Clark, Debbie Damon, Ehsan Ghorani, Adam Januszewski, Foteini Kalofonou, Ravindhi Murphy, Rajat Roy, Naveed Sarwar, Mark R. Openshaw, Michael J. Seckl   +15 more
doaj   +1 more source