Results 241 to 250 of about 3,600,121 (311)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Investigating Online Discussions About Cancer Screening on Twitter (Subsequently Rebranded as X): Corpus Analysis. [PDF]

JMIR Infodemiology
Jansen MP, Hendriks H, Verberne S, de Bruijn GJ, Das E.   +4 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Knowledge, Attitudes, and Uptake of Cervical Cancer Screening Among Female Students and Staff at a Tertiary Institution in Northern Uganda: A Cross-Sectional Study. [PDF]

Health Sci Rep
Anguyo M, Okello MO, Komakec D, Alyoomu E, Aziku H, Ouma RC, Pebolo PF.   +6 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Long-Term Regional Pathology-Detection Trends in High-Grade Cervical Lesions and Cervical Squamous Cell Carcinoma Among Women Aged 40-69 Years in Northern Norway, 1998-2025. [PDF]

Diagnostics (Basel)
Aas AH, Mortensen ES, Sørbye SW.
europepmc   +1 more source

Cost-effectiveness of abbreviated breast MRI and contrast-enhanced mammography for women with extremely dense breasts in a national breast cancer screening program: a micro-simulation study. [PDF]

Breast
Li M, Greuter MJW, Poelhekken K, Dorrius MD, Vermeulen KM, van Asselt ADI, de Bock GH.   +6 more
europepmc   +1 more source

Universal cervical length screening and vaginal progesterone: Distinguishing strategy effectiveness from treatment efficacy. [PDF]

Acta Obstet Gynecol Scand
Zethelius M, Bergman L, Ekelund AC, Vala CH, Jacobsson B, Kuusela P, Liljegren A, Lindkvist B, Petzold M, Sjögren P, Wennerholm UB, Wikström T.   +11 more
europepmc   +1 more source

Patient Preference and Adherence in Mammography Screening: A Narrative Review. [PDF]

Patient Prefer Adherence
Wang Y, Qi H, Zheng Y, Zhu W.
europepmc   +1 more source