Results 31 to 40 of about 7,150,903 (384)

Improved vectors and genome-wide libraries for CRISPR screening

Nature Methods, 2014
Genome-wide, targeted loss-of-function pooled screens using the CRISPR (clustered regularly interspaced short palindrome repeats)–associated nuclease Cas9 in human and mouse cells provide an alternative screening system to RNA interference (RNAi) and ...
Neville E. Sanjana, Ophir Shalem, Feng Zhang   +2 more
semanticscholar   +1 more source

Screening for Lung Cancer: US Preventive Services Task Force Recommendation Statement.

Journal of the American Medical Association (JAMA), 2021
Importance Lung cancer is the second most common cancer and the leading cause of cancer death in the US. In 2020, an estimated 228 820 persons were diagnosed with lung cancer, and 135 720 persons died of the disease.
A. Krist, K. Davidson, C. Mangione, M. Barry, M. Cabana, A. Caughey, E. Davis, Katrina E. Donahue, Chyke A Doubeni, Martha Y. Kubik, C. Landefeld, Li Li, G. Ogedegbe, D. Owens, L. Pbert, Michael Silverstein, J. Stevermer, Chien-Wen Tseng, J. Wong   +18 more
semanticscholar   +1 more source

Screening [PDF]

European Respiratory Journal, 2003
Screening for cancer is currently entering a very promising period as new technologies become available for assessment. However, this great opportunity also presents significant problems, starting with how do you select the likeliest method for evaluation?
openaire   +2 more sources

Sequential Screening [PDF]

The Review of Economic Studies, 1998
We present a model of price discrimination where a monopolistfaces a consumer who is privately informed about thedistribution of his valuation for an indivisible unit ofgood but has yet to learn privately the actual valuation.The monopolist sequentially screens the consumer with amenu of contracts:the consumer self-selects once by ...
Pascal Courty, Li Hao
openaire   +3 more sources

The adhesion and migration of microglia to β-amyloid (Aβ) is decreased with aging and inhibited by Nogo/NgR pathway

Journal of Neuroinflammation, 2018
Background Alzheimer’s disease is characterized by progressive accumulation of β-amyloid (Aβ)-containing amyloid plaques, and microglia play a critical role in internalization and degradation of Aβ. Our previous research confirmed that Nogo-66 binding to
Yinquan Fang, Jianing Wang, Lemeng Yao, Chenhui Li, Jing Wang, Yuan Liu, Xia Tao, Hao Sun, Hong Liao   +8 more
doaj   +1 more source

Sulfasalazine modifies metabolic profiles and enhances cisplatin chemosensitivity on cholangiocarcinoma cells in in vitro and in vivo models

Cancer & Metabolism, 2021
Background Sulfasalazine (SSZ) is widely known as an xCT inhibitor suppressing CD44v9-expressed cancer stem-like cells (CSCs) being related to redox regulation. Cholangiocarcinoma (CCA) has a high recurrence rate and no effective chemotherapy.
Malinee Thanee, Sureerat Padthaisong, Manida Suksawat, Hasaya Dokduang, Jutarop Phetcharaburanin, Poramate Klanrit, Attapol Titapun, Nisana Namwat, Arporn Wangwiwatsin, Prakasit Sa-ngiamwibool, Narong Khuntikeo, Hideyuki Saya, Watcharin Loilome   +12 more
doaj   +1 more source

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Journal of biomolecular screening, 1999
The ability to identify active compounds ("hits") from large chemical libraries accurately and rapidly has been the ultimate goal in developing high-throughput screening (HTS) assays.
Ji-Hu Zhang, T. Chung, K. Oldenburg
semanticscholar   +1 more source

Examining the benefits and harms of Alzheimer's disease screening for family members of older adults: study protocol for a randomized controlled trial [PDF]

, 2020
BACKGROUND: Multiple national expert panels have identified early detection of Alzheimer's disease and related dementias (ADRD) as a national priority.
Bakas, Tamilyn, Boustani, Malaz A., Callahan, Christopher M., Fowler, Nicole R., Gao, Sujuan, Head, Katharine J., Perkins, Anthony J., Suarez, Shelley D.   +7 more
core   +1 more source

Older Adults and Forgoing Cancer Screening [PDF]

, 2013
Although there is a growing recognition that older adults and those with extensive comorbid conditions undergo cancer screening too frequently, there is little information about patients’ perceptions regarding cessation of cancer screening.
Holtz, Laura R., Montz, Kianna, Sachs, Greg A., Schwartz, Peter H., Torke, Alexia M.   +4 more
core   +2 more sources

Combined primary carnitine deficiency with neonatal intrahepatic cholestasis caused by citrin deficiency in a Chinese newborn

BMC Pediatrics, 2020
Background Primary carnitine deficiency (PCD) is an autosomal recessive disorder affecting the carnitine cycle and resulting in defective fatty acid oxidation.
Yiming Lin, Weihua Lin, Yanru Chen, Chunmei Lin, Zhenzhu Zheng, Jianlong Zhuang, Qingliu Fu   +6 more
doaj   +1 more source