Results 51 to 60 of about 153,441 (267)

Impact of Plasma p‐tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Phosphorylated tau181 (p‐tau181), an Alzheimer's disease biomarker, was recently evaluated in amyotrophic lateral sclerosis (ALS). We investigated plasma p‐tau181 in 202 ALS/ALS‐FTD patients and 94 healthy controls, assessing cognitive performance, motor function, and longitudinal dynamics.
Elisabeth Kasper, Annaliis Lehto, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Vogt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Anja Schneider, Stefan Teipel, Johannes Prudlo, Andreas Hermann   +25 more
wiley   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Prevention of suicidal behavior in institutionalized elderly population: development and validation of a simulation script [PDF]

Revista Gaúcha de Enfermagem
Objective: To develop and validate the content of a simulation-based teaching script for the prevention of suicidal behavior in institutionalized elderly individuals, aimed at healthcare professionals and students. Method: Methodological study developed
Maria Isabella Alves Paterna, Camila Corrêa Matias Pereira, Aline Conceição Silva, Laysa Fernanda Silva Pedrollo, Kelly Graziani Giacchero Vedana   +4 more
doaj   +1 more source

Digital stories

Texto Livre: Linguagem e Tecnologia, 2020
Feedback is an important topic in education, and particularly for language development. This article intends to present some results of a research study aimed at investigating students’ perception concerning the feedback received during the script ...
Vanessa Rocha, Celso Henrique Soufen Tumolo   +1 more
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Clustering OKU Timur Script Images using VGG Feature extraction and K-Means

Jurnal Sisfokom
This study focuses on the utilization of clustering models to group manuscript images from the OKU Timur region based on specific characteristics. OKU Timur is rich in cultural heritage, including a unique writing system known as the OKU Timur script ...
Liu Toriko, Susan Dian Purnamasari, Yesi Novaria Kunang, Ilman Zuhri Yadi, Andri Andri   +4 more
doaj   +1 more source

Prevalence of Systemic Lupus Erythematosus in Australia, 2010–2022: A Population‐Based Study Using Linked National Administrative Health Data

Arthritis Care &Research, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a heterogenous inflammatory condition with widely varying global prevalence estimates. The frequency of SLE in the general population of Australia has been reported to be notably lower than contemporary estimates in countries such as the United States or United Kingdom, at 19 to 39 per 100,000 as opposed ...
Lucinda Roper, Rachel Black, Joanna Tieu, Winnie Chen, Matthew Parker, Catherine Hill, Natasha Nassar, Mandana Nikpour   +7 more
wiley   +1 more source

The application of artificial intelligence in film and television script creation

Discover Artificial Intelligence
This study discusses the application of artificial intelligence in film and television script creation, and analyzes the potential and challenges in script generation, plot construction and role development through machine learning and natural language ...
Zheyu Xu, Bingqin Xie
doaj   +1 more source

PERKEMBANGAN AKSARA KWADRAT DI JAWA TENGAH, JAWA TIMUR, DAN BALI: ANALISIS PALEOGRAFI

Forum Arkeologi, 2017
To date, kwadrat script always associated with Kadiri era from 12th century, so that it is known as “kwadrat kadiri”. Besides in Central Java and East Java, there are some inscriptions in Bali which use kwadrat script.
Titi Surti Nastiti
doaj   +1 more source