Results 51 to 60 of about 294 (255)
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
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Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
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Gephyra, 2011 This article is divided into four parts. Firstly, it notes the precedent provided by the conversion of the Roman theatre at Bosra in Syria into an Ayyubid Palace, for the conversion of the Roman theater into the Rum Seljuk palace at Belkis-Aspendos and ...
Terrance Michael Duggan
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
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Kristus ukřižovaný na palmě, „locus tristis“ a emblematika 17. století
Theatrum Historiae, 2012 The paper deals with a curious iconography of a stone relief decorating the statue of St. John of Nepomuk in Pecka town in the Eastern Bohemia. The unusual sculptural motif of Christ crucified on a palm leaf, which is held in the St.
Pavel Panoch
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‘To Make Britain Concrete Minded’: Peter László Peri’s London Life in Concrete (1938)
Open Library of HumanitiesIn 1938, sculptor Peter László Peri staged a solo exhibition in London titled London Life in Concrete, a selection of sculptural works fabricated out of concrete.
Tobah J Aukland-Peck
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الاكاديمي, 2016 The innate art,is a major tributary in the art world, It is a bold achievement, has a special flavor, With self-identity, linked to the origins and roots of human ,That goes back to the past and the history and culture of peoples.
KEFAH Abdul Majid
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ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers +7 more
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Reinforcing relief sculpture work: A key to proper adhesion
Journal of African History, Culture and Arts, 2022 The recent relief sculpture works showed lack of bonding properties for the work to last long. Therefore, this study sought to reinforce relief sculpture letters for better adhesion. A practice-based method was used, consisting of the following steps.
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