Results 51 to 60 of about 3,843,987 (249)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
'n Struktureel-historiese eksegese van Habakuk 1:2-2:4
In this article Hab 1:2-2:4 is subjected to a structural-historical exegesis. This means that both the text intern aspects (demarcation of the pericope, text critical matters and a structural analysis) and the text extern aspects (Gattung, Sitz im Leben,
SD Snyman
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
People at Bethlehem Cave, Bethlehem SD, Meade County
2 x 2 b/w negative, four people in front of a wood building with stone terracingOrigin: Publicity Division SD Dept. of Highways PierreBethlehem Cave.
SD Department of Highways
core +1 more source
Divine and human violence and destruction in Jeremiah 20:7-13
Jeremiah 20:7-13 is a text presenting the interpreter with a multitude of problems. Five main areas of research are briefly highlighted. This paper focuses on the interpretation of hamas wasod in Jer 20:8.
SD Snyman
doaj +1 more source
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies
Neurodegenerative proteinopathies are characterized by impaired protein clearance and the accumulation of misfolded or aggregated proteins, ultimately leading to neuronal death.
Georgie Lines +5 more
doaj +1 more source
Spearfish Canyon, Spearfish SD, Lawrence County
4 x 5 b/w negative, rugged canyon walls in a forested area with a well-traveled path at the lower central portion of the image5274A 96-290 Black Hills Spearfish Canyon Origin Publicity Division SD Dept. of Highways PierreSpearfish Canyon. 2075G-105. 3
SD Department of Highways
core

