Results 91 to 100 of about 40,683 (234)

Efficient identification of new small molecules targeting succinate dehydrogenase in non-small cell lung cancer

open access: yesCancer Cell International
Background Lung cancer treatment efficacy remains a challenge due to limited therapeutic targets. Succinate dehydrogenase (SDH) enzyme, a crucial enzyme linking the citric acid cycle and the electron transport chain, is implicated in cancer metabolism ...
Luis Silva   +8 more
doaj   +1 more source

Skeletal Muscle Fibre Type Determines Mitochondrial and Metabolic Responses to Hypoxia and Pulmonary Inflammation in Young Adult Rats. [PDF]

open access: yesJ Cachexia Sarcopenia Muscle
ABSTRACT Background Chronic obstructive pulmonary disease (COPD) patients often experience skeletal muscle dysfunction that may result from a complex combination of mitochondrial dysfunction, metabolic reprogramming and fibre type transitions. Among other factors, pulmonary inflammation and hypoxia contribute to the COPD‐associated muscle defects ...
Gavrielatos A   +7 more
europepmc   +2 more sources

Exploring the efficacy and safety of perampanel in epilepsia partialis continua: A case series

open access: yesEpileptic Disorders, EarlyView.
Abstract Background Epilepsia partialis continua (EPC) is a form of focal motor status epilepticus (SE), which is commonly drug‐resistant requiring treatment with multiple antiseizure medications (ASM). There are no established guidelines for pharmacological management.
Setareh Lahsaee   +3 more
wiley   +1 more source

Penerapan Penjamakan Sinkron Pada Jaringan SDH [PDF]

open access: yes, 2006
SDH (Synchronous Digital Hierarchy) is a multiplexing system based on TDM (Synchronous Digital Hierarchy) that is a frame is divided in to timeslot (path) and contains payload and overhead, which enable to transmit various different services and ...
Kholistianingsih, K. (Kholistianingsih)   +1 more
core   +1 more source

New telecom services over next generation SDH

open access: yes, 2005
Our main aim in this report is to use Next generation SDH to solve the problem associated with the new telecom services. We have tried to analyze the different services and in this way identified some drawbacks which can be seen as hindrances in ...
Syed, Jameel Ullah
core   +1 more source

Psychometric properties of the social determinants of health questionnaire (SDH-Q): development and validation

open access: yesBMC Public Health
Background The influence of social determinants of health (SDH) on sustainable development goals (SDG) has gained attention in recent years. However, there is a scarcity in the availability of valid and reliable instruments to assess the multiple aspects
Abdulwali Sabo   +5 more
doaj   +1 more source

Cloning, expression, purification and assay of sorbitol dehydrogenase from "Feicheng" peach fruit (Prunus persica)

open access: yesBrazilian Archives of Biology and Technology, 2013
A gene encoding NAD+-dependent sorbitol dehydrogenase (SDH) in peach fruit was cloned and expressed in Escherichia coli. Recombinant SDH protein with 6×His-tagged was localized exclusively in the cytoplasmic soluble fraction of E.
Zhen Sun   +3 more
doaj   +1 more source

Spatiospectral Photoacoustic Microscopy With Gain‐Switched Ti:Sapphire Laser for High‐Accuracy Molecular Dynamics Imaging

open access: yesLaser &Photonics Reviews, EarlyView.
Spatiospectral photoacoustic microscopy is enabled by stable, wavelength‐tunable dual‐pulse excitation from a gain‐switched Ti:sapphire laser. Intrinsically synchronized 532‐nm and NIR‐I pulses provide single‐scan, co‐registered mapping of oxygen saturation and indocyanine green dynamics in vivo.
Yong‐Jae Lee   +8 more
wiley   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek   +3 more
wiley   +1 more source

PERENCANAAN IMPLEMENTASI JARINGAN ETHERNET OVER SDH PADA OPERATOR TELEKOMUNIKASI(PLANNING OF ETHERNET OVER SDH NETWORK IMPLEMENTATION ON TELECOMMUNICATION OPERATOR) [PDF]

open access: yes, 2007
ABSTRAKSI: Pada era teknologi maju sekarang ini, kebutuhan pelanggan akan transmisi data yang cepat semakin meningkat dari hari ke hari.Oleh karena itu, setiap Operator Telekomunikasi berusaha untuk memberikan pelayanan yang sebaik-baiknya kepada para ...
DOAN RAMJANI
core  

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