Coumarin‐Based Antifungal Leads: Design, Synthesis, Mechanistic Insights, and Synergistic Activity
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.A series of novel coumarin derivatives are designed and synthesized as antifungal leads. The optimized compound IVd displays potent activity against plant pathogens, potential multitarget antifungal effects, and synergistic interactions with commercial fungicides, providing a promising strategy for resistance management.
Xiangna Chang +3 more
wiley +1 more source
Intra-operative acute subdural haematoma during elective craniotomy: Haemodynamic warning signs for the neuro-anaesthesiologist. [PDF]
Indian J AnaesthYadav S, Verma R, Gupta D, Sachan S.
europepmc +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.In gliomas, mitochondria integrate glucose, lipid, protein, and nucleotide metabolism to support proliferation, invasion, treatment resistance, and adaptation, with D‐2‐hydroxyglutarate‐driven remodeling in IDH‐mutant tumors and diverse metabolic states in IDH wild‐type glioblastomas.
Liangqi Jiang +4 more
wiley +1 more source
The Succinate-HIF-1α-NLRP3 Axis in 3-Nitropropionic Acid-Induced Ovarian Dysfunction: A Testable Metabolic-Inflammatory Framework. [PDF]
Biology (Basel)Zhang Z, Wang D, Lin Q, Guo P, Wang Z.
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Spinal Mechanisms of Testosterone Involved in Itch Regulation
CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.Testosterone serves as an endogenous anti‐pruritic hormone underlying sex‐dependent itch differences. In the spinal dorsal horn, testosterone binds androgen receptors on GABAergic interneurons to enhance GABA release, suppressing GRPR+ − pruriceptive neurons through GABAA receptors and alleviating acute/chronic itch alongside itch‐comorbid anxiety ...
Luying Chen +5 more
wiley +1 more source
Traumatic intracranial pseudoaneurysms of cortical middle cerebral artery and posterior cerebral artery branches presenting as subdural hematomas in elderly patients: A two-case report. [PDF]
Surg Neurol IntHassan KM +7 more
europepmc +1 more source
Health Science Reports, Volume 9, Issue 10, October 2026.ABSTRACT Background Young people in Ghana face heightened risks of sexually transmitted infections and unintended pregnancies, yet condom use remains inconsistent despite widespread awareness of HIV prevention strategies. Social capital, defined as the resources and support accessed through social networks, has emerged as a potentially important factor
Mark Kwame Ananga +4 more
wiley +1 more source
Rebalancing mitochondrial dynamics restores succinate dehydrogenase activity and reduces succinate release in hepatocellular carcinoma. [PDF]
J Biomed SciWu JY +6 more
europepmc +1 more source
Lactate dehydrogenase A exhibits sorbitol/fructose-related catalytic activity and contributes to polyol pathway metabolism in tumor cells. [PDF]
Front Endocrinol (Lausanne)Feng S, Hu Z, Tong H, Zhang H.
europepmc +1 more source
MedComm, Volume 7, Issue 10, October 2026.Alveolar macrophages: development, respiratory homeostasis, signal pathways, diseases, and therapeutic opportunities: During embryonic development, fetal progenitors migrate to the developing lungs via a CX3CR1‐dependent mechanism to establish the TrAM pool.
Sihan Yang +4 more
wiley +1 more source