Results 41 to 50 of about 40,683 (234)

Utility of the succinate:fumarate ratio for assessing SDH dysfunction in different tumor types

Molecular Genetics and Metabolism Reports, 2017
Objective: Mutations of genes encoding the four subunits of succinate dehydrogenase (SDH) have been associated with pheochromocytoma and paraganglioma (PPGLs), gastrointestinal stromal tumors (GISTs) and renal cell carcinomas (RCCs).
Edward Kim, Michael JP. Wright, Loretta Sioson, Talia Novos, Anthony J. Gill, Diana E. Benn, Christopher White, Trisha Dwight, Roderick J. Clifton-Bligh   +8 more
doaj   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Diseño de una red sdh para dar servicio de 1 stm-1 a una compañía celular del pais y asignar un e1 en la ciudad de manta para crear un call center hacia el nap de las americas con tdmoip [PDF]

, 2013
El presente estudio consiste en diseñar una red SDH que va permitir la comunicación entre dos ciudades importantes, Manta y Portoviejo en la provincia de Manabí- Ecuador.
Fiallos, Héctor, Parra Astudillo, Walter, Ramón Sanmartín, Gonzalo   +2 more
core  

SDH and MQO enzymatic activity measurements.

, 2023
The mitochondrial electron transport chain (mETC) is a series of membrane embedded enzymatic complexes critical for energy conversion and mitochondrial metabolism.
Sofia Sandalli (17616285), Andrew E. Maclean (10219517), Kiera Douglas (17616282), Mariana F. Silva (10219520), Lilach Sheiner (79023)   +4 more
core   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

The Assessment of Social Determinants of Health in Postsepsis Mortality and Readmission: A Scoping Review

Critical Care Explorations, 2022
OBJECTIVE:. To summarize knowledge and identify gaps in evidence about the relationship between social determinants of health (SDH) and postsepsis outcomes. DATA SOURCES:.
Ryan S. Hilton, BS, Katrina Hauschildt, PhD, Milan Shah, MD, Marc Kowalkowski, PhD, Stephanie Taylor, MD   +4 more
doaj   +1 more source

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

Recapitulating In Vivo Pharmacokinetics and Size‐Dependent Nanomedicine Delivery in a Microfluidic Platform

Advanced Science, EarlyView.
A microfluidic tumor platform integrates pharmacokinetic flow control, vascular‐like barriers, and 3D tumor spheroids to emulate in vivo drug exposure. The system reproduces dynamic concentration–time profiles and enables size‐dependent nanoparticle transport and efficacy evaluation, providing a predictive framework for assessing nanomedicine ...
Su Jeong Kang, Moon Sup Yoon, Jae Min Lee, Min Jeong Jo, Chae Eun Jin, Dae Hwan Shin   +5 more
wiley   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Model Pembelajaran Inkuiri Yurisprudensi untuk Mengembangkan Kemampuan Berpikir Kritis Siswa SD pada Pelajaran Pendidikan Agama Kristen [Jurisprudence Inquiry Learning Model to Develop Critical Thinking Skills of Elementary Students in Christian Religious Education Lessons]

Diligentia: Journal of Theology and Christian Education
Christian education views critical thinking skills as an important aspect because, through critical thinking skills, students are encouraged to differentiate between correct and incorrect information.
Kireina Gabriela Tumilantouw, Lindawati Lindawati   +1 more
doaj   +1 more source