Results 131 to 140 of about 1,160,569 (281)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
SDS-PAGE electrophoretic migration pattern of the H. volcanii S-layer protein.
, 2019 SDS-PAGE electrophoretic migration pattern of the H. volcanii S-layer protein.
Bernhard Schuster (6690011) +5 more
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
SDS-PAGE assay of RvEis and MsEis proteins.
, 2019 Equal amount of boiled and unboiled RvEis and MsEis proteins were electrophoresed on 8% SDS-PAGE gel. Lane 1- boiled RvEis, lane 2- unboiled RvEis, lane 3- boiled MsEis and lane 4- unboiled MsEis. H- Hexamer, T- Trimers and M- Monomers. Markers are shown
Shashi Anand (6504245) +2 more
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
SDS-PAGE separation and activity staining of expressed endomannanases.
, 2016 Left panel: Coomassie-blue stained SDS-PAGE; right panel: endomannanase zymogram. M: molecular weight marker; 1: Man5ATh; 2: Man5ATc; 3: Man5ATf. The molecular weight of the three endomannanases almost identical, in the size range 48–50 kDa.
Erna Szabó (2805967) +8 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
SDS-PAGE analysis of eluates from mannan-agarose affinity column.
, 2019 Plasma samples (5 mL) from Alligator and Common Snapping Turtles were filtered through a mannan-agarose affinity column in the presence of 20 mM Ca2+. Samples were eluted using EDTA buffer, concentrated and desalted using microcentrifugal concentrators ...
Sarah Baker (813920) +3 more
core +1 more source