Results 221 to 230 of about 24,482,269 (284)

La cigogne : ses noms, ses visages, ses voyages

, 2013
openaire   +1 more source

Safety, tolerability, pharmacokinetics and pharmacodynamics of the spleen tyrosine kinase inhibitor BI 894416 in healthy volunteers and patients with asthma

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Spleen tyrosine kinase (SYK) has broad biological functions in inflammation and immunity. The orally administered SYK inhibitor BI 894416 was investigated in a single‐rising‐dose Phase I study in healthy volunteers and in a combined single‐ and multiple‐rising‐dose Phase Ib study in patients with mild asthma ...
Saskia Carstensen‐Aurèche, Tobias Litzenburger, Dorothy De Sousa, Reinhard Sailer, Ewald Benediktus, Denis Delic, Fabian Müller, Meike Müller, Jens M. Hohlfeld   +8 more
wiley   +1 more source

Randomised, phase 1 evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of iptacopan in healthy volunteers

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Overactivation of the alternative pathway (AP) underlies several diseases. Iptacopan is an oral, first‐in‐class, highly potent specific inhibitor of factor B, a key AP protease. Experimental Approach The analysis included data from two phase 1 randomised, volunteer‐blinded, placebo‐controlled studies: Study 1, a single ...
Irina Baltcheva, Guido Junge, Kenneth Kulmatycki, Robert Schmouder, Anna Schubart, Marie‐Anne Valentin   +5 more
wiley   +1 more source

[The "good author"]. [PDF]

Rev Med Inst Mex Seguro Soc
Chávez-Martínez O.
europepmc   +1 more source

Testing the feasibility of an intermittent low‐energy diet in women with gestational diabetes

Diabetic Medicine, EarlyView.
Abstract Aims The study aimed to assess feasibility, acceptability and safety of an ILED in a randomised controlled trial of ILED vs. best NHS care healthy diet and exercise advice in women with Gestational Diabetes Mellitus (GDM) with body mass index ≥27.5 kg/m2 (≥25 kg/m2 in high‐risk minority ethnic groups) in the last trimester of pregnancy ...
Elizabeth Dapre, Emma Barrett, Brian McMillan, Andrea Pilkington, Fahmy Hanna, Avni Vyas, Cheryl Lombardelli, Womba Mubita, Jessy Athirampuzha, Liveen Dosanjh, Michelle Harvie, Basil G. Issa   +11 more
wiley   +1 more source

Impact of Treatment Delays in Epileptic Seizures: Time to Hospital Care and to EEG Increases Risk of Status Epilepticus and ICU Admission in Epileptic Seizures. [PDF]

Eur J Neurol
Sala Padró J, Fonseca E, Quintana M, Hernández Pérez G, López-Maza S, Campos-Fernández D, Abraira L, Santamarina E, Veciana de Las Heras M, Falip Centellas M, Toledo M.   +10 more
europepmc   +1 more source

Characterisation of steady‐state pharmacokinetics and glucodynamics of once‐weekly insulin efsitora alfa in individuals with type 2 diabetes

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To evaluate the steady‐state pharmacokinetics (PK) and glucodynamic effects of insulin efsitora alfa (efsitora) over a weekly interval in adults with type 2 diabetes (T2D). Materials and Methods This open‐label, multiple dose, euglycaemic clamp study was conducted in 56 insulin naïve adults with T2D (mean [±SD] age, 61.9 ± 5.98 years ...
Jennifer Leohr, Oliver Klein, Tim Heise, Eric Zijlstra, Juliana M. Bue‐Valleskey, Subha Suriyapperuma, Ryan Jarrett, Douglas James, Micheal Case, David Waters, Edward Pratt, Helle Linnebjerg   +11 more
wiley   +1 more source

[Dual Test in Pregnant Women: Case of a General Zone Hospital with Family Medicine]. [PDF]

Rev Med Inst Mex Seguro Soc
Reyes-Berlanga ML, De La Garza-Carranza MT, Sámano-Ortega VM.   +2 more
europepmc   +1 more source

Acarbose or Canagliflozin vs. Placebo to Ameliorate Post‐Bariatric Hypoglycaemia: The Clinical Outcomes of the HypoBar I Randomised Clinical Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Treatment options for post‐bariatric hypoglycaemia (PBH) are empirical. We aimed to investigate the efficacy and safety of acarbose and canagliflozin for the treatment of PBH. Materials and Methods We performed a randomised, double‐blinded, cross‐over, placebo‐controlled clinical trial where placebo, acarbose 50 mg thrice daily, and ...
Carolina B. Lobato, Clara Tornøe Winding, Kirstine N. Bojsen‐Møller, Bolette Hartmann, Christoffer Martinussen, Simon Veedfald, Jens J. Holst, Sten Madsbad, Nils Bruun Jørgensen, Carsten Dirksen   +9 more
wiley   +1 more source

[Impact of an integrated and centralized drug policy: the case of the province of Buenos Aires, ArgentinaImpacto de uma política de medicamentos integrada e centralizada: o caso da província de Buenos Aires, Argentina]. [PDF]

Rev Panam Salud Publica
Marín GH, Capallo AP, Cocco MH, Álvarez JI, Leone F, Pesci SA, Konfino J, Kreplak N.   +7 more
europepmc   +1 more source