Results 271 to 280 of about 10,366,637 (362)

Was Motorized Spiral Enteroscopy Too Risky? A Systematic Review and Meta‐Analysis Including German Registry Data

open access: yesUnited European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background and Study Aims Motorized spiral enteroscopy (MSE) was introduced as a major advancement in small‐bowel enteroscopy, enabling higher complete enteroscopy rates with shorter procedure times. However, after a fatal adverse event (AE) involving severe esophageal injury, the device was withdrawn from the market in July 2023.
Ingo Steinbrück   +19 more
wiley   +1 more source

Real‐World Safety Profile of Spesolimab in Generalized Pustular Psoriasis: Insights From Japan as Part of a Multinational Expanded Access Program (EAP)

open access: yesThe Journal of Dermatology, Volume 53, Issue 2, Page 351-356, February 2026.
ABSTRACT Generalized pustular psoriasis (GPP) is a heterogeneous, systemic neutrophilic inflammatory disease, characterized by chronic symptoms and recurrent flares, which can be potentially life‐threatening. Spesolimab, an interleukin‐36 receptor antagonist, has been approved to treat GPP flares in many countries including Japan.
Akimichi Morita   +12 more
wiley   +1 more source

Clinical and Molecular Effect of the Anti–IL‐18 Antibody Aletekitug in Adults With Atopic Dermatitis

open access: yesAllergy, Volume 81, Issue 2, Page 539-551, February 2026.
At Week 12, aletekitug was associated with a −68.3% percentage change from baseline in EASI score. Aletekitug improved the transcriptional profile of lesional skin towards that of non‐lesional skin at Week 4 and Week 12. Aletekitug was well‐tolerated; no serious adverse event or death occurred, and no patient withdrew due to an adverse event.
Joanne Ellis   +32 more
wiley   +1 more source

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